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PE anti-human CD269 (BCMA) Antibody

Pricing & Availability
Clone
19F2 (See other available formats)
Regulatory Status
RUO
Other Names
BCM, TNFRSF17
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
19F2_PE_CD269_Antibody_FC_032113
Human myeloma cell line U266 was stained with CD269 (clone 19F2) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
  • 19F2_PE_CD269_Antibody_FC_032113
    Human myeloma cell line U266 was stained with CD269 (clone 19F2) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
357503 25 tests 123€
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357504 100 tests 288€
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Description

CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells. It is expressed by plasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF and APRIL, and its cytoplasmic domain binds several of the TRAF family members.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BCMA-mouse IgG Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Ferguson ID, et al. 2022. Nat Commun. 13:4121. PubMed
  2. Montes de Oca R, et al. 2021. Mol Cancer Ther. 20:1941. PubMed
  3. Chen J, et al. 2020. Genome Biol. 0.980555556. PubMed
  4. Zah E, et al. 2020. Nat Commun. 11:2283. PubMed
  5. Alturaiki W, et al. 2021. Saudi J Biol Sci. 28:7455. PubMed
  6. den Hartog G, et al. 2018. Eur J Immunol. 48:283. PubMed
  7. Klein D, et al. 2021. Mol Ther. 29:2053. PubMed
  8. Nelke J, et al. 2020. MAbs. 12:1807721. PubMed
RRID
AB_2561925 (BioLegend Cat. No. 357503)
AB_2561926 (BioLegend Cat. No. 357504)

Antigen Details

Structure
Single pass transmembrane protein, member of the TNFR superfamily, 1 TNFR-Cys domain, 27 kD
Distribution

Plasmablasts, plasma cells, germinal center B cells

Function
B cell maturation factor, essential for survival of plasma cells
Interaction
Associates with several TRAF family members
Ligand/Receptor
BAFF, APRIL
Cell Type
B cells, Plasma cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Coquery CM and Erickson LD. 2012. Crit. Rev. Immunol. 32:287. 
2. Notas G, et al. 2012. J. Immunol. 189:4748. 
3. Rickert RC, et al. 2011. Immunol. Rev. 244:115. 
4. Mesin L, et al. 2011. J. Immunol. 187:2867.

Gene ID
608 View all products for this Gene ID
UniProt
View information about CD269 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 04/05/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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