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HRP anti-Transthyretin, 31-50 Antibody

Pricing & Availability
Clone
CPTC-TTR-1 (See other available formats)
Regulatory Status
RUO
Other Names
PALB, ATTR, Prealbumin, TBPA
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
CPTC-TTR-1_HRP_Transthyretin_Antibody_1_101118
Western blot of HRP anti-Transthyretin, 31-50 antibody (clone CPTC-TTR-1). Lane 1: Molecular weight marker; Lane 2: 100 ng of recombinant human transthyretin protein; Lane 3: 20 µg of human plasma. The blot was incubated with 5 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system. This antibody detects 16 kD monomer and high molecular weight aggregates of TTR in the human plasma sample.
  • CPTC-TTR-1_HRP_Transthyretin_Antibody_1_101118
    Western blot of HRP anti-Transthyretin, 31-50 antibody (clone CPTC-TTR-1). Lane 1: Molecular weight marker; Lane 2: 100 ng of recombinant human transthyretin protein; Lane 3: 20 µg of human plasma. The blot was incubated with 5 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system. This antibody detects 16 kD monomer and high molecular weight aggregates of TTR in the human plasma sample.
  • CPTC-TTR-1_HRP_Transthyretin_Antibody_2_101118
    IHC staining of HRP anti-Transthyretin, 31-50 antibody (clone CPTC-TTR-1) on formalin-fixed paraffin-embedded human liver tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 10 µg/ml of the primary antibody overnight at 4°C. DAB was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
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853004 100 µg 259€
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Description

Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant insoluble amyloid fibrils that primarily deposit in a patient’s heart and/or peripheral nerves. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70 years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC), affecting younger patients (in their 30s).Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant Human Transthyretin
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Preparation
The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Application

WB - Quality tested
IHC-P - Verified
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2783430 (BioLegend Cat. No. 853004)

Antigen Details

Structure
TTR is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
Distribution

Tissue sources: Liver, choroid plexus epithelium, and retina pigment epithelium.
Distribution: Primarily extracellular in blood and cerebrospinal fluid.

Function
The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
Interaction
Perlecan, receptor for advanced glycation end product (RAGE)
Ligand/Receptor
Thyroxine, retinol-binding protein bound to retinol
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
Carrier Proteins
Antigen References
  1. Plante-Bordeneuve V, et al. 2011. Lancet Neurol. 10:1086. PubMed
  2. Pinney JH, et al. 2013. J Am Heart Assoc. 2:e000098. PubMed
  3. Hawkins PN, et al. 2015. Ann Med. 47(8):625. PubMed
Gene ID
7276 View all products for this Gene ID
UniProt
View information about Transthyretin 31-50 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 02/13/2019

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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  • Purified anti-Transthyretin, 31-50

  • HRP anti-Transthyretin, 31-50
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