- CPTC-TTR-1 (See other available formats)
- Regulatory Status
- Other Names
- PALB, ATTR, Prealbumin, TBPA
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant insoluble amyloid fibrils that primarily deposit in a patient’s heart and/or peripheral nerves. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70 years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC), affecting younger patients (in their 30s).Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant Human Transthyretin
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783430 (BioLegend Cat. No. 853004)
- TTR is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
Tissue sources: Liver, choroid plexus epithelium, and retina pigment epithelium.
Distribution: Primarily extracellular in blood and cerebrospinal fluid.
- The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
- Perlecan, receptor for advanced glycation end product (RAGE)
- Thyroxine, retinol-binding protein bound to retinol
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Carrier Proteins
- Antigen References
- Gene ID
- 7276 View all products for this Gene ID
- View information about Transthyretin 31-50 on UniProt.org
|Purified anti-Transthyretin, 31-50||CPTC-TTR-1||WB,Direct ELISA|
|HRP anti-Transthyretin, 31-50||CPTC-TTR-1||WB,IHC-P|
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