- N278/19 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1, κ
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- Product Citations
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Synaptotagmin-3 (SYT3) is a member of the synaptotagmin family, which consists of 13 membrane trafficking proteins that contain a N-terminal transmembrane region, and two cytoplasmic C2 domains. Synaptotagmin-3 is mainly localized at the presynaptic terminals in the central nervous system, where it functions as a Ca2+ sensor and plays an important role in exocytosis of secretory vesicles and neurotransmitter release. It has been shown that Ca2+ influx triggers the interaction between the C2-domains of SYT3 and the phospholipid membranes.Product Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Host Species
- Fusion protein corresponding to amino acids 442-533 (cytoplasmic C2B domain) of mouse Synaptotagmin-3
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Not recommended to be used in WB with human brain lysate.
AB_2750416 (BioLegend Cat. No. 852603)
AB_2750417 (BioLegend Cat. No. 852604)
- Synaptotagmine-3 is a 590 amino acid protein with a molecular mass of ~ 63 kD.
Tissue Distribution: Central Nervous System
Cellular Distribution: Endosome, plasma membrane, synaptic vesicles, and cytosol.
- SYT3 functions as a Ca2+ sensor at the presynaptic terminals and plays a role in Ca2+-dependent exocytosis of secretory vesicles.
- SYT3 forms homodimers and heterodimers with SYT6, SYT9 and SYT10. It binds to SNARE-complex component syntaxin-1.
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Presynaptic proteins
- Antigen References
- Saheki Y, et al. 2017. Adv Exp Med Biol. 997:83
- Wang YL, et al. 2017. Cell Mol Life Sci. 74(16):2917
- Gene ID
- 84258 View all products for this Gene ID
- View information about Synaptotagmin-3 on UniProt.org
Related Pages & Pathways
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