FITC anti-human CD271 (NGFR) Antibody

Pricing & Availability
ME20.4 (See other available formats)
Regulatory Status
Other Names
p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, Nerve Growth Factor Receptor
Mouse IgG1, κ
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Product Citations
Human neuroblastoma cell line SK-N-MC stained with ME20.4 FITC
  • ME20.4_FITC_110309
    Human neuroblastoma cell line SK-N-MC stained with ME20.4 FITC
Compare all formats See FITC spectral data
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345103 25 tests 104€
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345104 100 tests 207€
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CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
WM245 melanoma cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications for the relevant formats include: immunoprecipitation1, Western blotting4, immunohistochemical staining of frozen or paraffin embedded tissue sections1,2, and blocking of NGF binding1.

Application References
  1. Ross A, et al. 1984. P. Natl. Acad. Sci. USA 81:6681. (FC, IP, Block, IHC)
  2. Cattoretti G, et al. 1993. Blood 81:1726. (IHC)
  3. Kamke MR, et al. 2005. Hear Res. 206:89.
  4. Baker D, et al. 1989. Cancer Res. 49:4142-4146. (FC, WB)
Product Citations
  1. Kagoya Y, et al. 2018. Nat Commun. 9:1915. PubMed
  2. Yoshida H, et al. 2020. Sci Rep. 1.249305556. PubMed
  3. Yamamoto K, et al. 2021. Cell Reports. 36(8):109576. PubMed
  4. Zuo J, et al. 2013. J Virol. 87:5340. PubMed
  5. Liu S, et al. 2021. Mol Ther. 29:1918. PubMed
  6. Lin JR et al. 2018. eLife. 7 pii: e31657. PubMed
  7. Li L, et al. 2020. J Transl Med. 18:363. PubMed
  8. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  9. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  10. Jann JC, et al. 2021. Nat Commun. 12:6170. PubMed
  11. Marelli S, et al. 2020. Elife. :9. PubMed
  12. Liu W, et al. 2020. Int J Biol Sci. 0.725694444. PubMed
  13. Guo D, et al. 2022. Elife. 11:. PubMed
  14. Shalabi SF, et al. 2021. Nat Aging. 1:838. PubMed
  15. Bonny AR, et al. 2021. Nat Commun. 12:292. PubMed
  16. Dige A, et al. 2019. Gastroenterology. 156:2208. PubMed
  17. Aomatsu E, et al. 2014. Sci Rep. 4:3652. PubMed
  18. Naamati A, et al. 2019. Elife. 8:e41431. PubMed
  19. Kowal JM, et al. 2021. Stem Cell Res Ther. 12:265. PubMed
  20. Nakatsugawa M, et al. 2015. J Immunol. 194 3487 . PubMed
  21. Nakatsugawa M, et al. 2016. Sci Rep. 6:23821. PubMed
  22. Tencerova M, et al. 2021. Stem Cell Res Ther. 12:586. PubMed
  23. Ochi T, et al. 2015. Cancer Immunol Res. 3: 1070-1081. PubMed
  24. Rodrigues Toste de Carvalho AL, et al. 2021. Nat Protoc. 16:1802. PubMed
  25. Jia L, et al. 2022. Ann Transl Med. 10:482. PubMed
  26. Murata K, et al. 2020. Elife. 9:. PubMed
  27. Kowal JM, et al. 2019. Stem Cells Transl Med. 0.50625. PubMed
AB_1937226 (BioLegend Cat. No. 345103)
AB_2282828 (BioLegend Cat. No. 345104)

Antigen Details

Type I transmembranal protein with a MW of 75 kD. The extracellular portion contains four TNFR-Cys repeats that form the NGF binding domain; the intracellular portion contains a death domain.

Expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, melanocytes.

Apoptosis, differentiation, neurogenesis.
Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Neurotrophin 3. (NTF3) , Neurotrophin 4 (NTF4)
Apoptosis, differentiation, neurogenesis.
Cell Type
Dendritic cells, Mesenchymal cells, Mesenchymal Stem Cells, Neurons
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, Postsynaptic proteins
Antigen References

1. Friedman MJ, et al. 2009. J. Biol. Chem. 284:27944.
2. Rock JR, et al. 2009. Proc Natl Acad Sci USA. 106:12771.
3. Kidd SK, et al. 2008. Brain Res.1195:113.
4. Peters EM, et al. 2007. Am J Pathol. 171:1872.
5. Jansen P, et al. 2007. Nat Neurosci. 10:1449.

Gene ID
4804 View all products for this Gene ID
View information about CD271 on

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Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD271 (NGFR)

  • FITC anti-human CD271 (NGFR)

  • PE anti-human CD271 (NGFR)

  • APC anti-human CD271 (NGFR)

  • PE/Cyanine7 anti-human CD271 (NGFR)

  • PerCP/Cyanine5.5 anti-human CD271 (NGFR)

  • Alexa Fluor® 647 anti-human CD271 (NGFR)

  • Alexa Fluor® 700 anti-human CD271 (NGFR)

  • PE/Dazzle™ 594 anti-human CD271 (NGFR)

  • APC/Fire™ 750 anti-human CD271 (NGFR)

  • Biotin anti-human CD271 (NGFR)

  • TotalSeq™-A0816 anti-human CD271 (NGFR)

  • APC/Cyanine7 anti-human CD271 (NGFR)

  • TotalSeq™-C0816 anti-human CD271 (NGFR)

  • TotalSeq™-B0816 anti-human CD271 (NGFR)

  • Pacific Blue™ anti-human CD271 (NGFR) Antibody


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