Biotin anti-human PTX3 Antibody

Pricing & Availability
MNB4 (See other available formats)
Regulatory Status
Other Names
PTX-3, Pentraxin 3, TSG-14, TNFAIPS, Tumor Necrosis Factor Inducible Gene 14 Protein, Tumor Necrosis Factor Alpha-Induce Protein 5, TNF Alpha-Induced Protein 5
Rat IgG2a, κ
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Product Citations
Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).
  • RECOM_HU_PTX3_080119.png
    Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).
Cat # Size Price Quantity Check Availability Save
538004 100 µg 259€
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PTX3 is part of the pentraxin family which is characterized by a cyclic multimeric structure. Penatraxins are acute phase proteins that act as pattern recognition receptors. PTX3 is a long pentraxin containing a C terminal domain similar to other members of the pentraxin family and a unique N terminal domain. Inflammatory signals stimulate PTX3 production by a variety of cells including mononuclear phagocytes, dendritic cells, fibroblasts, and endothelial cells.

Serum levels of PTX3 increase rapidly in response to a variety of inflammatory and infectious conditions including endotoxic shock and sepsis. PTX3 has been proposed as an early diagnostic marker for septic shock. PTX3 can activate the classical complement pathway, aiding in pathogen recognition by macrophages and dendritic cells. PTX3 is also believed to play an important role in protection against autoimmunity by enhancing complement-mediated clearing of apoptotic cells and restricting cross presentation. Current research has also indicated that PTX3 is involved in initiating the process of tissue repair and plays a role in female fertility. PTX3 is believed to be involved in cancer-related inflammation and high PTX3 levels have been correlated with clinical stage and severity for various cancers.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant Human PTX3
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

ELISA Detection - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Detection applications, a concentration range of 0.2 - 0.8 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of PTX3 recombinant protein ranging from 6000 to 93.75 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The biotinylated MNB4 (Cat. No. 538004) antibody is useful as the detection antibody in a sandwich ELISA assay, when used in conjunction with the pure MNB5 antibody (Cat. No. 537902) as the capture antibody and Recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).

AB_2814448 (BioLegend Cat. No. 538004)

Antigen Details


Dendritic cells, Endothelial cells, Fibroblasts, Monocytes

Plays roles in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components, and female fertility.
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Monocytes
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Innate Immunity
Gene ID
5806 View all products for this Gene ID
View information about PTX3 on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 1    Revision Date: 08/01/2019

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  • Biotin anti-human PTX3


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