Biotin anti-human CD357 (GITR) Antibody

Pricing & Availability
108-17 (See other available formats)
Regulatory Status
Other Names
TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR
Mouse IgG2a, κ
Ave. Rating
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Product Citations
Human peripheral blood lymphocytes were activated for three days with PHA, and then stained with CD3 FITC and biotinylated CD357 (clone 108-17, top) or biotinylated mouse IgG2a, κ isotype control (bottom), followed by Sav-PE.
  • 108-17_Biotin_CD357_Antibody_1_050817
    Human peripheral blood lymphocytes were activated for three days with PHA, and then stained with CD3 FITC and biotinylated CD357 (clone 108-17, top) or biotinylated mouse IgG2a, κ isotype control (bottom), followed by Sav-PE.
  • 108-17_Biotin_CD357_Antibody_2_050817
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371220 100 µg 212€
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GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant human GITR-Fc chimera
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

AB_2687167 (BioLegend Cat. No. 371220)

Antigen Details

TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD.

Activated lymphocytes.

Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2/NIK pathway.
Cell Type
Lymphocytes, Tregs
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. van der Werf N, et al. 2011. J. Immunol. 187:1411.
2. Shimizu J, et al. 2002. Nat. Immunol. 3:135.
3. McHugh RS, et al. 2002. Immunity 16:311.
4. Kwon B, et al. 1999. J. Biol. Chem. 274:6056.

Gene ID
8784 View all products for this Gene ID
View information about CD357 on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 0    Revision Date: 05/09/2017

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD357 (GITR)

  • Brilliant Violet 421™ anti-human CD357 (GITR)

  • PE anti-human CD357 (GITR)

  • APC anti-human CD357 (GITR)

  • Alexa Fluor® 488 anti-human CD357 (GITR)

  • Brilliant Violet 605™ anti-human CD357 (GITR)

  • PerCP/Cyanine5.5 anti-human CD357 (GITR)

  • PE/Cyanine7 anti-human CD357 (GITR)

  • Biotin anti-human CD357 (GITR)

  • Brilliant Violet 711™ anti-human CD357 (GITR)

  • APC/Fire™ 750 anti-human CD357 (GITR)

  • Alexa Fluor® 647 anti-human CD357 (GITR)

  • TotalSeq™-A0360 anti-human CD357 (GITR)

  • TotalSeq™-C0360 anti-human CD357 (GITR)

  • Brilliant Violet 750™ anti-human CD357 (GITR)

  • TotalSeq™-B0360 anti-human CD357 (GITR)

  • TotalSeq™-D0360 anti-human CD357 (GITR)


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