- 4G2 (See other available formats)
- Other Names
- 19A, CS1, CD319, CRACC
- Rat IgG1, κ
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- Product Citations
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CD319/CD319/CS1/CRACC/SLAMF7 is a 66 kD transmembrane protein belonging to the CD2 subset of the immunoglobulin superfamily; it is expressed on most NK cells, B cells, and subsets of T cells. CD319 activates immune responses in NK cells when coupled with SAP-family adaptors (SAP, EAT-2, ERT) and inhibits immune responses in the absence of SAP-family adaptors or when bound to SH-domain molecules.Product Details
- Antibody Type
- Host Species
- CD319-Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
AB_2632674 (BioLegend Cat. No. 152003)
AB_2632675 (BioLegend Cat. No. 152004)
- Extracellular domain with one Ig like V-set domain and one Ig like C2-set domain, and an cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs.
- Spleen, lymph node, bone marrow, testis, thymus; NK cells, B cells, and subsets of T cells.
- Activates immune responses in NK cells when coupled with SAP-family adaptors (SAP, EAT-2, ERT).
- Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN, and SAP-family adaptors (SAP, EAT-2, ERT).
- Cell Type
- NK cells, B cells, T cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Li Y, et al. 2013. PLoS One 8(9):e76681.
2. Dongre P, et al. 2013. Mol. Immunol. 54:254-63.
3. Tovar V, et al. 2002. Immunogenetics 54:394.
4. Dong Z, et al. 2009. Nat. Immunol. 10:973.
- Gene ID
- 75345 View all products for this Gene ID
- View information about CD319 on UniProt.org
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