Beyond the code laid out by your DNA sequences and genetics, there is another layer of control that can dictate which genes are activated or silenced. Epigenetics are heritable, reversible forms of gene modification that function independently of the DNA sequence. Common examples include DNA methylation, histone methylation, acetylation, phosphorylation and ubiquitination. Epigenetic modifications are being studied in several disease models as detailed by Heerboth et al. below. BioLegend provides a diverse set of products for the detection of both histones and their epigenetic modifications.
Adapted from: Heerboth, S. et al. 2014. Genetics and Epigenetics. 6:9. Pubmed
Chromatin can be found in the heterochromatin (condensed) form. Histone acetyl transferases (HATs) place acetyl groups on histones, causing them to de-condense into the euchromatin state, allowing for the transcription of their genes. This process can be reversed with histone deacetylases (HDACs). These processes have been implicated in several areas, including cancer, metabolism, and neurological disorders. In cancer cells, DNMT1, an enzyme that methylates CpG regions, is often found to be highly upregulated. This hypermethylation recruits HDACs and can silence tumor suppressing genes, promoting tumor development. CpG methylation is also tightly regulated in neuron development. Mutations, duplications, or insertion of the methyl CpG binding protein 2 (MeCP2) gene has been found to lead to Rett syndrome, a rare postnatal neurological disorder that occurs primarily in females.

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Human, Mouse, and Rat Antibodies

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HDAC1 Poly6074 Human, Mouse
HDAC2 3F3/HDAC2 Human, Mouse, Rat
HDAC3 3G6 Human, Mouse
HDAC4 14A9C47 Human
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HDAC6 18E2SC Human
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Histone H3 (C-terminus) 1B1-B2 Human, Mouse, Rat
Histone H3 Dimethyl (Lys9) 5E5-G5 Human, Rat
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Histone H3 Phospho (Ser10) 11D8 Human
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Histone H3 Trimethyl (Lys9) 6F12-H4 Human, Rat
Histone H4 Monomethyl (Lys20) 5E10-D8 Human, Mouse, Rat
Histone H4 Trimethyl (Lys 20) 6F8-D9 Human, Mouse, Rat
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Recombinant Proteins

Recombinant Human HMGB1 (carrier-free)
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