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- Clone
- 8G7G3/1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Thyroid Transcription Factor, Homeobox protein Nkx-2.1, thyroid nuclear factor 1, thyroid transcription factor 1 TTF-1 NK-2
- Previously
-
Signet Catalog# 830-26 L2 Predilute
Covance Catalog# SIG-3830
- Isotype
- Mouse IgG1
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
IHC staining of purified anti-TTF-1 antibody (clone 8G7G3/1) on formalin-fixed paraffin-embedded human lung tumor tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm -
IHC staining of purified anti-TTF-1 antibody (clone 8G7G3/1) on formalin-fixed paraffin-embedded rat lung tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 918101 | 6 mL | 246€ | ||||
Transcription termination factor-1 (TTF-1) plays a critical role in ribosomal gene transcription. This transcription factor mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. It binds to and activates the promoter of thyroid specific genes such as thyroglobulin, thyrotropin receptor, and thyroperoxidase. TTF-1 is important in the maintenance of the thyroid differentiation phenotype.
Product DetailsProduct Details
- Verified Reactivity
- Human, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This antibody was developed using a rat TTF-1 recombinant protein.
- Formulation
- Phosphate-buffered solution with BSA + 0.1% NaN3.
- Preparation
- The antibody was purified by affinity chromatography.
- Storage & Handling
- Store between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, the antibody is ready-to-use.
- Application Notes
-
The BioLegend TTF-1 (8G7G3/1) antibody recognizes the 40kD thyroid transcription factor, which is a member of the NKx2 family of transcription factors. TTF-1 antigen is expressed in epithelial cells of the thyroid gland and the lung.
- RRID
-
AB_2565205 (BioLegend Cat. No. 918101)
Antigen Details
- Biology Area
- Cell Biology, Signal Transduction
- Gene ID
- 25628 View all products for this Gene ID
- UniProt
- View information about TTF-1 on UniProt.org
Related FAQs
Other Formats
View All TTF-1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-TTF-1 | 8G7G3/1 | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-TTF-1
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