- GL3 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor γ/δ
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, which is involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. γ/δ TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8- although some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Armenian Hamster
- C57BL/6J intraepithelial lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F, IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The GL3 antibody has been shown to be useful in identifying γ/δ T cells by flow cytometry and immunohistochemistry and depleting γ/δ T cells in vivo. Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone-fixed frozen sections2,6, and in vivo depletion of γ/δ T cells3-5.
(PubMed link indicates BioLegend citation)
- Goodman T, et al. 1989. J. Exp. Med. 170:1569. (FC, IP)
- Cardona AE, et al. 2003. Infect. Immun. 71:2634. (IHC)
- Kapp JA, et al. 2004. Immunology 111:155. (Deplete)
- Skelsey ME, et al. 2001. J. Immunol. 166:4327. (Deplete)
- Ke Y, et al. 1997. J. Immunol. 158:3610. (Deplete)
- Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
- Kasten KR, et al. 2010. Infect. Immun. 78:4714. (FC) PubMed
- Stadanlick JE, et al. 2011. J. Immunol. 187:664. PubMed
- Van Belle AB, et al. 2012. J. Immunol. 188:462. PubMed
- Product Citations
AB_313826 (BioLegend Cat. No. 118101)
- Ig superfamily, associates with CD3 complex.
T cell subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum, most γ/δ T cells are CD4-/CD8-, some are CD8+.
- Antigen recognition; γ/δ T cells are thought to play a role in tolerance.
- Some bacterial or tumor antigens bound to MHC class I.
- Cell Type
- Epithelial cells, T cells, Tregs
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
- Skarstein K, et al. 1995. Immunology. 81:497.
- Harrison LC, et al. 1996. J Exp Med. 184:2167.
- Wildner G, et al. 1996. Eur J Immunol. 26:2140.
- Brandes M, et al. 2005. Science. 309:264.
- Gene ID
- 110066 View all products for this Gene ID 110067 View all products for this Gene ID
- View information about TCR gamma/delta on UniProt.org
Related Pages & Pathways
Other FormatsView All TCR γ/δ Reagents Request Custom Conjugation
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|FITC anti-mouse TCR γ/δ||GL3||FC|
|PE anti-mouse TCR γ/δ||GL3||FC,SB|
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|Brilliant Violet 605™ anti-mouse TCR γ/δ||GL3||FC|
|Brilliant Violet 510™ anti-mouse TCR γ/δ||GL3||FC|
|Alexa Fluor® 647 anti-mouse TCR γ/δ||GL3||FC|
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|TotalSeq™-A0121 anti-mouse TCR γ/δ||GL3||PG|
|Ultra-LEAF™ Purified anti-mouse TCR γ/δ||GL3||FC,IHC-F,IP|
|TotalSeq™-C0121 anti-mouse TCR γ/δ||GL3||PG|
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|TotalSeq™-B0121 anti-mouse TCR γ/δ||GL3||PG|
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Compare Data Across All Formats
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Brilliant Violet 421™ anti-mouse TCR γ/δ
Purified anti-mouse TCR γ/δ
Biotin anti-mouse TCR γ/δ
FITC anti-mouse TCR γ/δ
PE anti-mouse TCR γ/δ
APC Anti-mouse TCR γ/δ
PerCP/Cyanine5.5 anti-mouse TCR γ/δ
PE/Cyanine7 anti-mouse TCR γ/δ
Alexa Fluor® 488 anti-mouse TCR γ/δ
Brilliant Violet 605™ anti-mouse TCR γ/δ
Brilliant Violet 510™ anti-mouse TCR γ/δ
Alexa Fluor® 647 anti-mouse TCR γ/δ
APC/Fire™ 750 anti-mouse TCR γ/δ
TotalSeq™-A0121 anti-mouse TCR γ/δ
Ultra-LEAF™ Purified anti-mouse TCR γ/δ
TotalSeq™-C0121 anti-mouse TCR γ/δ
APC/Cyanine7 anti-mouse TCR γ/δ
TotalSeq™-B0121 anti-mouse TCR γ/δ