Purified anti-mouse IL-23R Antibody anti-IL-23R

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Clone: 12B2B64 (See other available formats)
Regulatory Status: RUO
Other Names: Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17
Isotype: Rat IgG2b, κ
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Product Citations: publications

12B2B64_Pure_IL-23R_Antibody_123015 — Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with purified IL-23R (clone 12B2B64) (filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE.

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150902

100 µg

221€

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Description

IL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells. It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells. Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial mouse IL-23R recombinant protein (aa 24-374)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2566431 (BioLegend Cat. No. 150902)

Antigen Details

Structure: 72 kD protein that associates with IL-12RB1 to form a heterodimer.
Function: Involved in IL-23A signaling.
Interaction: JAK2 and STAT3.
Ligand/Receptor: IL-23/IL23A.
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: 1. Parham C, et al. 2002. J. Immunol. 168:5699.
2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204.
3. Harris TJ, et al. 2007. J. Immunol. 179:4313.
4. Zhang XY, et al. 2006. Immunogenetics 57:934.
5. Awasthi A, et al. 2009. J. Immunol. 182:5904.
Gene ID: 209590 View all products for this Gene ID
UniProt: View information about IL-23R on UniProt.org

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Other Formats

View All IL-23R Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse IL-23R	12B2B64	FC
PE anti-mouse IL-23R	12B2B64	FC
APC anti-mouse IL-23R	12B2B64	FC
Brilliant Violet 421™ anti-mouse IL-23R	12B2B64	FC
TotalSeq™-A1033 anti-mouse IL-23R	12B2B64	PG
TotalSeq™-C1033 anti-mouse IL-23R	12B2B64	PG

Certificate of Analysis

Go To Top Version: 1 Revision Date: 01/05/2016

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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