- 3/23 (See other available formats)
- Regulatory Status
- Other Names
- Bp50, TNFRSF5
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant mouse CD40 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 124627 &124628) with a low endotoxin limit (Endotoxin < 0.01 EU/µg).
(PubMed link indicates BioLegend citation)
- Hasbold J, et al. 1994. Eur. J. Immunol. 24:1835.
- Bourgeois C, et al. 2002. Science 297:2060.
- Product Citations
AB_1134239 (BioLegend Cat. No. 124601)
AB_1134240 (BioLegend Cat. No. 124602)
- 48 kD type I transmembrane glycoprotein, a member of the tumor necrosis factor receptor (TNFR) superfamily.
Expressed on B lymphocytes and other antigen-presenting cells, such as macrophages, follicular dendritic cells, etc.
- Regulates B cell growth and differentiation and Ig isotype switching. Interaction of CD40 with its ligand, CD154, on activated T cells is important for immune response.
- CD154 on T cells
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
1. Grewal IS, et al. 1998. Annu Rev Immunol 16:111.
- Gene ID
- 21939 View all products for this Gene ID
- View information about CD40 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD40 Reagents Request Custom Conjugation
|Purified anti-mouse CD40||3/23||FC,IHC-F|
|Biotin anti-mouse CD40||3/23||FC|
|FITC anti-mouse CD40||3/23||FC|
|PE anti-mouse CD40||3/23||FC|
|APC anti-mouse CD40||3/23||FC|
|Alexa Fluor® 647 anti-mouse CD40||3/23||FC|
|PE/Cyanine5 anti-mouse CD40||3/23||FC|
|PE/Cyanine7 anti-mouse CD40||3/23||FC|
|Ultra-LEAF™ Purified anti-mouse CD40||3/23||FC|
|PerCP/Cyanine5.5 anti-mouse CD40||3/23||FC|
|Pacific Blue™ anti-mouse CD40||3/23||FC|
|PE/Dazzle™ 594 anti-mouse CD40||3/23||FC|
|APC/Fire™ 750 anti-mouse CD40||3/23||FC|
|TotalSeq™-C0903 anti-mouse CD40||3/23||PG|
|TotalSeq™-A0903 anti-mouse CD40||3/23||PG|
|APC/Cyanine7 anti-mouse CD40||3/23||FC|
|TotalSeq™-B0903 anti-mouse CD40 Antibody||3/23||PG|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-mouse CD40
Biotin anti-mouse CD40
FITC anti-mouse CD40
PE anti-mouse CD40
APC anti-mouse CD40
Alexa Fluor® 647 anti-mouse CD40
PE/Cyanine5 anti-mouse CD40
PE/Cyanine7 anti-mouse CD40
Ultra-LEAF™ Purified anti-mouse CD40
PerCP/Cyanine5.5 anti-mouse CD40
Pacific Blue™ anti-mouse CD40
PE/Dazzle™ 594 anti-mouse CD40
APC/Fire™ 750 anti-mouse CD40
TotalSeq™-C0903 anti-mouse CD40
TotalSeq™-A0903 anti-mouse CD40
APC/Cyanine7 anti-mouse CD40
TotalSeq™-B0903 anti-mouse CD40 Antibody