- 1H6B44 (See other available formats)
- Regulatory Status
- Other Names
- Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, 60S ribosomal protein L27a histidine hydroxylase, Histone lysine demethylase MINA, MYC-induced nuclear antigen, Nucleolar protein 52 (NO52), Ribosomal oxygenase MINA (ROX), MDIG
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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MINA, also known as Mineral dust-induced gene (MDIG), is a member of the JmjC family of proteins and can act as a histone lysine demethylase and a ribosomal histidine hydroxylase. MINA is implicated in the demethylation of K9 trimethylated histone H3 (H3K9me3), regulating cell proliferation and survival. MINA has been suggested to be a novel oncogene associated with a variety of cancers. Elevated expression of MINA in human tumors has been linked to malignancy and poor prognosis. MINA has been identified as a transcriptional co-repressor of IL-4 gene and participates in the regulation of Th2 differentiation and Th2 bias. MINA appears to be a regulator of the Treg/Th17 balance by promoting differentiation of Th-17 cells and inhibiting FOXP3 expression.Product Details
- Antibody Type
- Host Species
- Partial recombinant protein (300-465 aa) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2566795 (BioLegend Cat. No. 683302)
- 465 amino acids with a predicted molecular weight of 52.8 kD. Contains a JmjC domain responsible for lysine demethylation of histones.
Nucleus and nucleolus.
- MINA is an oxygenase exerting histone lysine demethylase and ribosomal histidine hydroxylase activities. It is involved in cell proliferation, survival, and T cell differentiation.
- MINA interacts with Srp72, NOP56, RPL10, EIF3E, HNRNPU, RNPS1, RPL35, and RRBP1.
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. Thakur C, et al. 2015. Genes Cancer 6:288.
2. Pillai MR, et al. 2014. Curr. Opin. Immunol. 31:38.
3. Lian S, et al. 2013. PLoS One 8:e80638.
4. Hemmers S, et al. 2009. Nat. Immunol. 10:806.
5. Lu Y, et al. 2009. Cell Cycle. 8:2101.
6. Tsuneoka M, et al. 2004. Clin. Cancer Res. 10:7347.
- Gene ID
- 84864 View all products for this Gene ID
- View information about MINA on UniProt.org
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