Purified anti-IL-27 p28 Antibody

Pricing & Availability
B0315A10 (See other available formats)
Regulatory Status
Other Names
Interleukin-27 Subunit Alpha, IL-27 (28K subunit)
Mouse IgG2b, κ
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Product Citations
Western blot analysis of 50 ng recombinant human IL-27 (lane 1) and recombinant mouse IL-27 (lane 2) using anti-IL-27 P28 antibody (clone B0315A10) and HRP anti-mouse IgG antibody.
  • B0315A10_Purified_IL-27_p28_Antibody_WB_050115
    Western blot analysis of 50 ng recombinant human IL-27 (lane 1) and recombinant mouse IL-27 (lane 2) using anti-IL-27 P28 antibody (clone B0315A10) and HRP anti-mouse IgG antibody.
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676902 100 µg 184€
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IL-27 is a heterodimeric cytokine that is composed of two subunits (p28 and EBI3). It plays a critical role in T-cell proliferation and differentiation. It also drives rapid clonal expansion of naive but not memory CD4 T cells. IL-27 is a potent inhibitor of Th17 cell development and IL-17 production. IL-27 subunit p28 alone is able to inhibit the production of IL-17 by CD4 and CD8 T cells. Furthermore, IL-27 plays an important role in antitumor and antiangiogenic activity through the increase in the production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant human IL-27.
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

AB_2565723 (BioLegend Cat. No. 676902)

Antigen Details

A heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40 related protein) and p28 (a newly discovered IL-12 p35-related protein).

Monocytes, macrophages, and dendritic cells (DCs).

T cell proliferation and differentiation.
Activated T cells, resting natural killer cells (NK), resting NKT cells, neutrophils, eosinophils, mast cells, hepatic stellate cells, hepatoma cells, and hepatocytes.
IL-27RA, also known as WSX-1 or TCCR, paired with gp130.
Cell Type
B cells, Dendritic cells, Macrophages, Monocytes
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
Antigen References

1. Pflanz S, et al. 2002. Immunity 16:779.
2. Owaki T, et al. 2005. J. Immunol. 175:2191.
3. Batten M, et al. 2006. Nat. Immunol. 7:929.
4. Villarino AV, et al. 2006. J. Immunol. 176:237.
5. Stumhofer JS, et al. 2007. Nat. Immunol. 8:1363.
6. Awasthi A, et al. 2007. Nat. Immunol. 8:1380.
7. Pot C, et al. 2009. J. Immunol. 183:797.
8. Bender H, et al. 2009. Hepatology 50:585.
9. Bosmann M and Ward PA. 2013. J. Leukoc. Biol. 94:1159.

Gene ID
246778 View all products for this Gene ID
View information about IL-27 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 06/14/2022

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  • Purified anti-IL-27 p28


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