- B0315A10 (See other available formats)
- Regulatory Status
- Other Names
- Interleukin-27 Subunit Alpha, IL-27 (28K subunit)
- Mouse IgG2b, κ
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- Product Citations
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IL-27 is a heterodimeric cytokine that is composed of two subunits (p28 and EBI3). It plays a critical role in T-cell proliferation and differentiation. It also drives rapid clonal expansion of naive but not memory CD4 T cells. IL-27 is a potent inhibitor of Th17 cell development and IL-17 production. IL-27 subunit p28 alone is able to inhibit the production of IL-17 by CD4 and CD8 T cells. Furthermore, IL-27 plays an important role in antitumor and antiangiogenic activity through the increase in the production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant human IL-27.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2565723 (BioLegend Cat. No. 676902)
- A heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40 related protein) and p28 (a newly discovered IL-12 p35-related protein).
Monocytes, macrophages, and dendritic cells (DCs).
- T cell proliferation and differentiation.
- Activated T cells, resting natural killer cells (NK), resting NKT cells, neutrophils, eosinophils, mast cells, hepatic stellate cells, hepatoma cells, and hepatocytes.
- IL-27RA, also known as WSX-1 or TCCR, paired with gp130.
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Antigen References
1. Pflanz S, et al. 2002. Immunity 16:779.
2. Owaki T, et al. 2005. J. Immunol. 175:2191.
3. Batten M, et al. 2006. Nat. Immunol. 7:929.
4. Villarino AV, et al. 2006. J. Immunol. 176:237.
5. Stumhofer JS, et al. 2007. Nat. Immunol. 8:1363.
6. Awasthi A, et al. 2007. Nat. Immunol. 8:1380.
7. Pot C, et al. 2009. J. Immunol. 183:797.
8. Bender H, et al. 2009. Hepatology 50:585.
9. Bosmann M and Ward PA. 2013. J. Leukoc. Biol. 94:1159.
- Gene ID
- 246778 View all products for this Gene ID
- View information about IL-27 on UniProt.org
|Purified anti-IL-27 p28||B0315A10||WB|
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