- 7H20-I19-M3 (See other available formats)
- Other Names
- Interleukin 21
- Mouse IgG1, κ
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- Product Citations
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Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.Product Details
- Human, Cross-Reactivity: Mouse* - weak affinity
- Antibody Type
- Host Species
- Recombinant full length human IL-21
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store frozen between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 µg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
AB_1227666 (BioLegend Cat. No. 514302)
- Cell Sources
- NK-T cells and T cells
- Cell Targets
- cytotoxic T cells (CTL) and Natural Killer (NK) cells, that can destroy malignant or infected cells
- Cell Type
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Nurieva R,et al. 2007. Nature 448:416.
2. Parrish-Novak J, et al. 2002. J. Leukocyte Biol. 72:856.
3. Dumoutier L, et al. 2000. Proc. Natl. Acad. Sci. USA 97:10144.
4. Asao H, et al. 2001. J. Immunol. 167:1.
5. Parrish-Novak J, et al. 2000. Nature 408:57.
- Gene ID
- 59067 View all products for this Gene ID 60505 View all products for this Gene ID
- View information about IL-21 on UniProt.org
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