- 14G2a (See other available formats)
- Regulatory Status
- Other Names
- Disialoganglioside GD2, Ganglioside G2
- Mouse IgG2a, κ
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- Product Citations
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Ganglioside GD2 is a sialic acid-containing glycosphingolipid involved in cell attachment to the extracellular matrix. Expression of GD2 in normal tissue is restricted to cells from the central nervous system, peripheral nerves, skin melanocytes, and mesenchymal stem cells. However GD2 is highly expressed by tumors of neuro-ectodermal origin such as melanomas, gliomas, neuroblastomas, and small cell lung carcinoma. GD2 has been proposed as a marker for some cancer stem cells.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Neuroblastoma cell line LAN-1
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 14G2a is an isotype switch variant from parental hybridoma 14.18 (IgG3)1. Additional reported applications (for the relevant formats) include: inducing apoptosis and enhancing cytotoxicity of chemotherapeutic drugs in the neuroblastoma cell line 2. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for use in cytotoxic and apoptotic studies (contact our custom solutions team). This clone has also been published as 14.G2a.
(PubMed link indicates BioLegend citation)
- Mujoo K, et al. 1989. Cancer Res. 49:2857. (Cyt)
- Kowalczyk A, et al. 2009. Cancer Lett. 281:171. (Apop, Cyt)
- Battula VL, et al. 2012. J. Clin. Invest. 122:2066. (FC)
AB_2561883 (BioLegend Cat. No. 357302)
Neurons, mesenchymal stem cells, highly expressed in tumors of neuro-ectodermal origin, such as melanomas, gliomas, neuroblastomas, and small cell lung carcinoma
- Cell attachment to extracellular matrix
- Cell Type
- Mesenchymal cells, Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Immunology, Neuroscience
- Molecular Family
- Adhesion Molecules
- Antigen References
1. Tarek N, et al. 2012. J. Clin. Invest. 122:3260.
2. Matthay KK, et al. 2012. Clin. Cancer Res. 18:2740.
3. Navid F, et al. 2010. Curr. Cancer Drug Targets. 10:200.
- Gene ID
- 2583 View all products for this Gene ID
- View information about Ganglioside GD2 on UniProt.org
Related Pages & Pathways
Other FormatsView All Ganglioside GD2 Reagents Request Custom Conjugation
|Purified anti-human Ganglioside GD2||14G2a||FC|
|PE anti-human Ganglioside GD2||14G2a||FC|
|APC anti-human Ganglioside GD2||14G2a||FC|
|PE/Cyanine7 anti-human Ganglioside GD2||14G2a||FC|
|Biotin anti-human Ganglioside GD2||14G2a||FC|
|PerCP/Cyanine5.5 anti-human Ganglioside GD2||14G2a||FC|
|FITC anti-human Ganglioside GD2||14G2a||FC|
|Brilliant Violet 510™ anti-human Ganglioside GD2||14G2a||FC|
|Alexa Fluor® 647 anti-human Ganglioside GD2||14G2a||FC|
|PE/Dazzle™ 594 anti-human Ganglioside GD2||14G2a||FC|
|APC/Fire™ 750 anti-human Ganglioside GD2||14G2a||FC|
|APC/Cyanine7 anti-human Ganglioside GD2||14G2a||FC|
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Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human Ganglioside GD2
PE anti-human Ganglioside GD2
APC anti-human Ganglioside GD2
PE/Cyanine7 anti-human Ganglioside GD2
Biotin anti-human Ganglioside GD2
PerCP/Cyanine5.5 anti-human Ganglioside GD2
FITC anti-human Ganglioside GD2
Brilliant Violet 510™ anti-human Ganglioside GD2
Alexa Fluor® 647 anti-human Ganglioside GD2
PE/Dazzle™ 594 anti-human Ganglioside GD2
APC/Fire™ 750 anti-human Ganglioside GD2
APC/Cyanine7 anti-human Ganglioside GD2