Purified anti-human CD360 (IL-21R) Antibody

Pricing & Availability
2G1-K12 (See other available formats)
Regulatory Status
Other Names
IL-21 Receptor, novel interleukin receptor (NILR)
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes were cultured overnight with (bottom) or without (top) recombinant human IL-21, then surface stained with purified 2G1-K12 conjugated to PE and CD19 APC
  • IL-21R_top_041910
    Human peripheral blood lymphocytes were cultured overnight with (bottom) or without (top) recombinant human IL-21, then surface stained with purified 2G1-K12 conjugated to PE and CD19 APC
  • IL-21R_zbottom_041910
    Human peripheral blood lymphocytes were cultured overnight with (bottom) or without (top) recombinant human IL-21, then surface stained with purified 2G1-K12 conjugated to PE and CD19 APC
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347802 100 µg 212€
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The human interleukin 21 receptor (IL-21R), is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits the greatest extracellular homology to the IL-2R beta subunit, i.e., contains one copy of the WSXWS-containing cytokine-binding domain. Intracellular domains of IL-21R include the Box 1 and Box 2 elements which are similar to the IL-9R intracellular region. Upon binding IL-21, the IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Host Species
IL-21R transfected Ba/F3 cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Rodrigues-Bayona B, et al. 2012. J. Immunol. 188:1578. PubMed
AB_2044031 (BioLegend Cat. No. 347802)

Antigen Details

Single pass type I membrane protein, extracellular WSXWS-containing cytokine-binding domain, intracellular Box1 and Box2 domains

B cells, various levels on NK cells and T cells

Cell Type
B cells, NK cells, T cells, Tregs
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Parish-Novak J, et al. 2000. Nature 408:57.
2. Ozaki K, et al. 2000. Proc Natl. Acad. Sci. USA. 97:11439.
3. Dumoutier L, et al. 2000. Proc Natl. Acad. Sci. USA. 97:10144.
4. Asao H, et al. 2001. J. Immunol. 167:1.
5. Parish-Novak J, et al. 2002. J. Leukocyte Biol. 72:856.
6. de Torero D, et al. 2006. Blood 107:3708.
7. Davis ID, et al.2007. Clin Cancer Res. 13:6926.
8. Nurieva R, et al. 2007. Nature 448:4416.

Gene ID
50615 View all products for this Gene ID
View information about CD360 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 3    Revision Date: 08/16/2022

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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