- QA20B10 (See other available formats)
- Regulatory Status
- Other Names
- CTLA4, Cytotoxic T-Lymphocyte Antigen 4, CTLA-4
- Mouse IgG1, κ
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- Product Citations
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CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. It is transiently expressed on activated T cells. CTLA-4 is expressed on the surface of helper T cells and transmits an inhibitory signal to T cells. Regulatory T cells express high levels of CTLA-4. CTLA-4 is similar to CD28 in amino acid sequence, structure, and genomic organization. Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells (APC). CTLA-4 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone QA20B10 can completely block the binding of parental clone to target cells.
AB_2936635 (BioLegend Cat. No. 385402)
- Ig superfamily and 33 kD
Activated T cells and B cells
- Negative regulator of T cell activation
- Antigen presenting cells
- B7-1 (CD80), B7-2 (CD86)
- Antigen References
- Kuiper HM, et al. 1995. J Immunol. 155:1776-83.
- Pistillo MP, et al. 2003. Blood. 101:202-9.
- Tan PH, et al. 2005. Blood. 106:2936-43.
- Steiner K, et al. 2001. Clin Exp Immunol. 126:143-50.
- Gene ID
- 1493 View all products for this Gene ID
- View information about CD152 on UniProt.org
|Purified anti-human CD152 (CTLA-4) Recombinant Antibody||QA20B10||ICFC|
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