Purified anti-human CD124 (IL-4Rα) Antibody

Pricing & Availability
G077F6 (See other available formats)
Regulatory Status
Other Names
IL-4 receptor α subunit
Mouse IgG2a, κ
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Product Citations
Human peripheral blood lymphocytes were stained with CD19 APC and purified CD124 (clone G077F6) (top) or mouse IgG2a, κ isotype control (bottom), followed by anti-mouse IgG2a PE.
  • G077F6_Pure_1_070212
    Human peripheral blood lymphocytes were stained with CD19 APC and purified CD124 (clone G077F6) (top) or mouse IgG2a, κ isotype control (bottom), followed by anti-mouse IgG2a PE.
  • G077F6_Pure_2_070212
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355001 25 µg 81€
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355002 100 µg 175€
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CD124, also known as the alpha subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13.  A truncated form of IL-4Rα exists in the soluble form in biological fluids. CD124 is expressed on human B and T cells as well as a variety of other hematopoietic and non-hematopoietic cells and cell lines.  In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for non-hematopoietic cell responses to IL-4 or IL-13.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant human IL-4Rα Fc chimera
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

AB_11219392 (BioLegend Cat. No. 355001)
AB_11219599 (BioLegend Cat. No. 355002)

Antigen Details

140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit

B cells, T cells, endothelial cells, cancer cells

Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells
IL-4, IL-13
Cell Type
B cells, Endothelial cells, T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Kashiwada M, et al. 2001. J. Immunol. 167:6382.
  2. Gilmour J, et al. 2008. Immunology 124:437.
  3. Hage T, et al. 1999. Cell 97:271.
Gene ID
3566 View all products for this Gene ID
View information about CD124 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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