- BL28633 (See other available formats)
- Other Names
- CAT, Epididymis Secretory Sperm Binding Protein
- Mouse IgG2a, κ
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- Product Citations
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Catalase is a heme-containing homotetrameric protein that decomposes hydrogen peroxide to water and oxygen to prevent the generation of hydroxyl radicals in cells. The role of catalase in cellular oxidative stress defense has been widely studied. Overexpression of catalase renders cells more resistant to hydrogen peroxide-induced toxicity and oxidant-mediated injury from hypoxia. Transgenic mice overexpressing catalase are protected against myocardial injury following adriamycin treatment. Although catalase knockout mice develop normally, they show differential sensitivity to oxidant tissue injury. Brain is particularly vulnerable to oxidative stress. Abnormalities and dysfunction of catalase have been indicated in neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. Catalase activity was shown to be reduced in Parkinson-derived substantia nigra and putamen tissues. In in vitro cellular models of Alzheimer’s disease, aggregated amyloid beta demonstrates high affinity for catalase leading to the accumulation of hydrogen peroxide and increased oxidative stress.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant Catalase
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 2.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Human Catalase is a 527 amino acid protein with a molecular mass of 60 kD.
Tissue distribution: Ubiquitously expressed; highly expressed in bone marrow and liver.
Cellular distribution: Peroxisome and nucleus
- Catalase is an antioxidant enzyme involved in the body defense against oxidative stress.
- Cell Targets
- Hydrogen peroxide.
- Cell Type
- Astrocytes, Neurons
- Biology Area
- Cell Biology, Cell Death, Neurodegeneration, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
- Ho YS, et al. 2004. J Biol Chem. 279(31):32804-12.
- Ambani LM, et al. 1975. Arch Neurol. 32(2):114-8.
- Milton NG. 1999. Biochem J. 344(Pt 2): 293–296.
- Habib LK, et al. 2010. J Biol Chem. 285(50):38933-43
- Gene ID
- 547 View all products for this Gene ID
- View information about Catalase on UniProt.org
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