- A17188B (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG2b, κ
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Programmed cell death protein 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant human CD279 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
A17188B antibody can block the binding of NAT105 and EH12.2H7 antibodies to the target.
AB_2832833 (BioLegend Cat. No. 621613)
AB_2832834 (BioLegend Cat. No. 621614)
- 55 kD type I transmembrane protein
Transiently expressed on CD4- and CD8- thymocytes, upregulated in thymocytes and splenic T and B lymphocytes, and is expressed on activated myeloid cells.
- Signaling and co-stimulation (co-inhibition)
- SHP-1 and SHP-2
- PD-L1 (CD274) and PD-L2 (CD273)
- Cell Type
- Lymphocytes, T cells
- Biology Area
- Cell Biology, Immuno-Oncology, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
- Ishida Y, et al. 1992. EMBO J. 11:3887
- Francisco LM, et al. 2010. Immunol Rev. 236:219
- Gene ID
- 5133 View all products for this Gene ID
- View information about CD279 on UniProt.org
Related Pages & Pathways
- How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?
PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.
Other FormatsView All CD279 Reagents Request Custom Conjugation
|Ultra-LEAF™ Purified anti-human CD279 (PD-1)||A17188B||Block|
|Purified anti-human CD279 (PD-1)||A17188B||FC|
|PE anti-human CD279 (PD-1)||A17188B||FC|
|APC anti-human CD279 (PD-1)||A17188B||FC|
|FITC anti-human CD279 (PD-1)||A17188B||FC|
|PerCP/Cyanine5.5 anti-human CD279 (PD-1)||A17188B||FC|
|PE/Cyanine7 anti-human CD279 (PD-1)||A17188B||FC|
|TotalSeq™-D1169 anti-human CD279 (PD-1)||A17188B||PG|
|APC/Fire™ 810 anti-human CD279 (PD-1)||A17188B||FC|
|PE/Fire™ 640 anti-human CD279 (PD-1)||A17188B||FC|
|PE/Fire™ 700 anti-human CD279 (PD-1)||A17188B||FC|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Ultra-LEAF™ Purified anti-human CD279 (PD-1)
Purified anti-human CD279 (PD-1)
PE anti-human CD279 (PD-1)
APC anti-human CD279 (PD-1)
FITC anti-human CD279 (PD-1)
PerCP/Cyanine5.5 anti-human CD279 (PD-1)
PE/Cyanine7 anti-human CD279 (PD-1)
TotalSeq™-D1169 anti-human CD279 (PD-1)
APC/Fire™ 810 anti-human CD279 (PD-1)
PE/Fire™ 640 anti-human CD279 (PD-1)
PE/Fire™ 700 anti-human CD279 (PD-1)