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PE/Cyanine7 anti-human CD191 (CCR1) Antibody

Pricing & Availability
Clone
5F10B29 (See other available formats)
Regulatory Status
RUO
Other Names
CKR1, CD191, HM145, SCYAR1, CMKRB1
Isotype
Mouse IgG1, κ
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Product Citations
publications
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362913 25 tests 128€
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362914 100 tests 296€
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Description

CD191, also known as CCR1, is a 41 kD, G-protein coupled receptor expressed predominantly by monocytes. CCR1 is also expressed by a subset of T cells and eosinophils. CCR1 positive cells can migrate in response to a CCL3 and CCL5 gradient. CCR1 knock-out studies suggest that this molecule plays an important role in inflammation and susceptibility to viruses and parasites.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CCR1 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Product Citations
  1. Liechti T, et al. 2022. Nat Commun. 13:7255. PubMed
  2. Yang JY, et al. 2020. J Cell Mol Med. . PubMed
RRID
AB_2734400 (BioLegend Cat. No. 362913)
AB_2734401 (BioLegend Cat. No. 362914)

Antigen Details

Structure
G-protein coupled receptor, seven transmembrane protein, 41 kD
Distribution

Monocytes, macrophages, subset of T cells, eosinophils

Function
Regulates migration of cells in response to CCL3 and CCL5
Ligand/Receptor
CCL3 and CCL5
Cell Type
Eosinophils, Macrophages, Monocytes, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Su SB, et al. 1996. J. Leuko. Biol. 60:658.
2. Su S, et al. 1997. Blood. 90:605.
3. Ayehunie S, et al. 1997. Blood. 90:1379.
4. Gerard C, et al. 1997. J. Clin. Invest. 100:2022.
5. Tiffany HL, et al. 1998. J. Immunol. 160:1385.
6. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194.
7. Bednar F, et al. 2014. J. Immunol. 192:5305.

Gene ID
1230 View all products for this Gene ID
UniProt
View information about CD191 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05/11/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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