- 11C7C49 (See other available formats)
- Other Names
- Histone deacetylase 7, HD7, HDAC7a, HDAC 7, HDAC-7
- Mouse IgG1, κ
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- Product Citations
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Histone deacetylases (HDACs) regulate a variety of biological processes by deacetylating lysine residues in the N-terminal tails of core histones and non-histone proteins. HDAC7 is a class IIa histone deacetylase and its enzymatic activity is dependent on the interaction with HDAC3. HDAC7 is highly expressed in CD4+CD8+ double-positive thymocytes and has been suggested to repress the expression of Nur77 through the transcription factor MEF2D. HDAC7 is mostly localized to the nucleus and can be sequestrated in the cytoplasm by interacting with 14-3-3 protein during T cell receptor activation. The nuclear export of HDAC7 leads to the expression of Nur77 and apoptosis. HDAC7 has been shown to regulate the maturation of osteoclast and osteoblast, as well as the development of muscle and blood vessel.Product Details
- Antibody Type
- Host Species
- Synthetic HDAC7 peptide conjugated to KLH (1-17 a.a.)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ChIP - Quality tested
WB - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by ChIP Assay. The suggested dilution for ChIP application is 1:50-1:100 by volume. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml.
It is recommended that the reagent to be titrated for optimal performance before each experiment.
- Application Notes
25 µg, 100 µg of Go-ChIP-GradeTM Purified Antibody can be used for 2-4, 11-16 immunoprecipitations, respectively, at the recommended dilution.
AB_2687137 (BioLegend Cat. No. 683503)
AB_2687138 (BioLegend Cat. No. 683504)
- 952 amino acids with a predicted molecular weight of 102.9 kD. Contains a histone deacetylase domain.
Cytoplasm and the nucleus.
- HDAC7 mediates deacetylation of lysine residues in the N-terminal tails of core histones. It plays important roles in the regulation of T-cell differentiation and development of muscle and blood vessel.
- HDAC7 interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, FOXP3, KAT5, EDNRA, KDM5B, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors
- Antigen References
1. Barneda-Zahonero B, et al. 2013. PLoS Genet. 9:e1003503.
2. Pham L, et al. 2011. J. Biol. Chem. 286:12056.
3. Li S, et al. 2011. Mol. Cancer 10:18.
4. Gao C, et al. 2010. Biochim. Biophys. Acta. 1803:1186.
5. Margariti A, et al. 2009. J. Cell. Sci. 122:460.
6. Parra M, et al. 2007. Genes Dev. 21:638.
- Gene ID
- 51564 View all products for this Gene ID
- View information about HDAC7 on UniProt.org
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