- S16001E (See other available formats)
- Regulatory Status
- Other Names
- ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled
- Mouse IgG2a, κ
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- Product Citations
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P2RY12 is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system and is not activated by UDP and UTP.
P2RY12 is required for normal platelet aggregation and blood coagulation, and is a target to inhibit of platelet aggregation in the treatment of thromboembolisms and other clotting disorders. P2RY12 is expressed on platelets, lung, appendix, pituitary and adrenal glands; this molecule is a very useful marker to identify microglial cells in the brain.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Human P2RY12-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research.
AB_2876707 (BioLegend Cat. No. 392107)
AB_2876707 (BioLegend Cat. No. 392108)
- Inhibit the adenylyl cyclase second messenger system
- ADP, ATP
- Cell Type
- Microglia, Platelets
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- GPCR, Purinergic Receptors
- Antigen References
1. Lecchi A, et al. 2015. Blood. 125:1006.
2. Zhang K, et al. 2014. Nature. 509:115.
3. Zhang J, et al. 2014. Nature. 509:119.
4. Cornelissen I, et al. 2010. Proc. Natl. Acad. Sci. USA. 107:18605.
5. Paruchuri S, et al. 2009. J. Exp. Med. 206:2543.
- Gene ID
- 64805 View all products for this Gene ID
- View information about P2RY12 on UniProt.org
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