- MRP 1H9 (See other available formats)
- Regulatory Status
- Other Names
- S100A9, Migration inhibitory factor-related proteins-14, Calgranulin-B, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
MRP-14, also known as S100A9, belongs to the S100 family of proteins containing 2-EF-hand calcium-binding motifs. It forms non-covalently associated complexes with another S100 family member, MRP-8. MRP14 is expressed in neutrophils and monocytes; it also has been found in ileal tissue eosinophils. The S100A8/A9 complex has been shown to play a role during calcium-dependent activation as well as have antibacterial, antifungal, immunomodulating, and anti-proliferative effects. It also functions as a chemoattractant factor for neutrophils and has been considered an endogenous activator of Toll-like receptor 4. S100A9 has been identified as a marker for CD14(+) HLA-DR(-/low) MDSCs.Product Details
- Antibody Type
- Host Species
- Recombinant human MRP-14
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
This clone has been published as 1H9.
Additional reported applications (for the relevant formats) include: Western blotting1 and immunohistochemical staining with paraffin-embedded tissue sections1,2.
(PubMed link indicates BioLegend citation)
- Robinson MJ, et al. 2002. J. Biol. Chem. 277:3658. (WB, IHC)
- Croce K, et al. 2009. Circulation 120:427. (IHC)
- Andricovich J, et al. 2016. J. Clin. Invest. 126:905. (ICFC) Pubmed
AB_10662414 (BioLegend Cat. No. 350703)
AB_10662250 (BioLegend Cat. No. 350704)
- Belongs to S100 family of proteins containing 2-EF-hand calcium -binding motifs, forms non-covalently associated complexes with another S100 family member MRP-8
MDSCs, neutrophils, monocyte, and ileal tissue eosinophils
- Calcium-dependent activation, immunomodulating and antiproliferative, endogenous activator of Toll-like receptor 4
- Cell Type
- Neutrophils, Monocytes, Eosinophils
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Adhesion Molecules
- Antigen References
1. Loser K, et al. 2010. Nat. Med. 16:713.
2. Cheng P, et al. 2008. J. Exp. Med. 205:2235.
3. Leukert N, et al.2006. J. Mol. Biol. 359:961.
4. Lagasse E, et al. 1988. Mol. Cell. Biol. 8:2402.
5. Zhao F, et al. 2012. Immunology. 136:176.
- Gene ID
- 6280 View all products for this Gene ID
- View information about MRP-14 on UniProt.org
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.