FITC anti-human CD103, CD103, Ber-ACT8

Pricing & Availability

Analyte Specific Reagent. Analytical and performance characteristics are not established.

Clone: Ber-ACT8
Workshop: V A067
Other Names: Integrin alpha E (ITGAE)
Isotype: Mouse IgG1, κ

Ber-ACT8_FITC_CD103_ASR_020323 — Typical results from PHA-stimulated (3 days) human peripheral blood lymphocytes stained either with Ber-ACT8 FITC used at 5 µL/test (filled histogram) or with an isotype control (open histogram)

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984806

500 µL

200€

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Description

CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Product Details

Technical Data Sheet (pdf)

Product Details

Reactivity

Human

Formulation

Phosphate-buffered solution, pH7.2, 0.09% sodium azide, 0.2% (w/v) BSA (origin USA), and a stabilizer.

Preparation

The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.

Concentration

50 µg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

Suggested for Flow Cytometry

Disclaimer

WARNINGS AND PRECAUTIONS

Use appropriate personal protective equipment and safety practices per universal precautions when working with this reagent. Refer to the reagent safety data sheet.
This antibody contains sodium azide. Follow federal, state and local regulations to dispose of this reagent. Sodium azide build-up in metal wastepipes may lead to explosive conditions; if disposing of reagent down wastepipes, flush with water after disposal.
All specimens, samples and any material coming in contact with them should be considered potentially infectious and should be disposed of with proper precautions and in accordance with federal, state and local regulations.
Do not use this reagent beyond the expiration date stated on the label.
Do not use this reagent if it appears cloudy or if there is any change in the appearance of the reagent as these may be an indication of possible deterioration.
Avoid prolonged exposure of the reagent or stained cells to light.

Antigen Details

Antigen References

Parker CM, et al. 1992. Proc Natl Acad Sci USA. 89:1924-8.
Kruschwitz M, et al. 1991. J Clin Pathol. 44:636-45.
Schon MP, et al. 1999. J Immunol. 162:6641-9.
Shaw SK, et al. 1994. J Biol Chem. 269:6016-25.

Documentation

Certificate of Analysis

Go To Top Version: 1 Revision Date: 02/16/2023

Analyte Specific Reagent. Analytical and performance characteristic are not established.

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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