- Ber-ACT8 (See other available formats)
- Regulatory Status
- V A067
- Other Names
- Integrin alpha E (ITGAE)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.Product Details
- Verified Reactivity
- Reported Reactivity
- Antibody Type
- Host Species
- HTLV-1 induced human T cell line MAPS16
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: Western Blotting1, immunoprecipitation1, and immunohistochemical staining of frozen tissue sections1.
(PubMed link indicates BioLegend citation)
- Kruschwitz M, et al. 1991. J. Clin. Pathol. 44:636. (WB, IP, IHC-F)
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
AB_2876662 (BioLegend Cat. No. 350237)
AB_2876662 (BioLegend Cat. No. 350238)
- Type I transmembrane glycoprotein, integrin family; can be cleaved into 150 kD and 25 kD chains; associated with β7 integrin
Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells; expressed on hairy cell leukemia
- Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulation of tissue-specific T cell homing
- Cell Targets
- Integrin β7
- Cell Type
- Dendritic cells, Lymphocytes, T cells, Tregs
- Biology Area
- Cell Biology, Immunology, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Parker CM, et al. 1992. P. Natl. Acad. Sci. USA 89:1924.
2. Kruschwitz M, et al. 1991. J. Clin. Pathol. 44:636.
3. Schon MP, et al. 1999. J. Immunol. 162:6641.
4. Shaw SK, et al. 1994. J. Biol. Chem. 269:6016.
- Gene ID
- 3682 View all products for this Gene ID
- View information about CD103 on UniProt.org
Related Pages & Pathways
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Purified anti-human CD103 (Integrin αE)
FITC anti-human CD103 (Integrin αE)
PE anti-human CD103 (Integrin αE)
Alexa Fluor® 488 anti-human CD103 (Integrin αE)
Alexa Fluor® 647 anti-human CD103 (Integrin αE)
PE/Cyanine7 anti-human CD103 (Integrin αE)
Brilliant Violet 421™ anti-human CD103 (Integrin αE)
APC anti-human CD103 (Integrin αE)
Brilliant Violet 605™ anti-human CD103 (Integrin αE)
Biotin anti-human CD103 (Integrin αE)
Brilliant Violet 711™ anti-human CD103 (Integrin αE)
PE/Dazzle™ 594 anti-human CD103 (Integrin αE)
PerCP/Cyanine5.5 anti-human CD103 (Integrin αE)
Brilliant Violet 785™ anti-human CD103 (Integrin αE)
APC/Cyanine7 anti-human CD103 (Integrin αE)
TotalSeq™-A0145 anti-human CD103 (Integrin αE)
TotalSeq™-C0145 anti-human CD103 (Integrin αE)
TotalSeq™-B0145 anti-human CD103 (Integrin αE)
APC/Fire™ 750 anti-human CD103 (Integrin αE)
PE/Fire™ 700 anti-human CD103 (Integrin αE) Antibody
TotalSeq™-D0145 anti-human CD103 (Integrin αE)
PE/Fire™ 640 anti-human CD103 (Integrin αE)
PE anti-human CD103
FITC anti-human CD103