APC anti-mouse CD140a Antibody

Pricing & Availability
APA5 (See other available formats)
Regulatory Status
Other Names
PDGF receptor-α, PDGFR-α
Rat IgG2a, κ
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Product Citations
Mouse fibroblast NIH/3T3 cells stained with APA5 APC
  • APA5_APC_030510
    Mouse fibroblast NIH/3T3 cells stained with APA5 APC
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135907 25 µg 72€
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135908 100 µg 214€
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Platelet-derived growth factor receptor-α (PDGFR-α), CD140a, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs: PDGF-AA, PDGF-AB, and PDGF-BB. PDGFRa is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140a is expressed on embryonic tissues and mesenchymal-derived cells of adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Mouse PDGFR-α-hIgG1 recombinant fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported (for relevant formats) applications include: Western Blot, blocking function2, and immunohistochemical staining of paraffin and frozen sections. The LEAF™ purified antibody is recommended for functional assays.

Application References

(PubMed link indicates BioLegend citation)
  1. Takakura N, et al. 1996. J. Invest. Dermatol. 107:770.
  2. Liao C, et al. 2010. J. Clin. Invest. 120:242. (Block)
  3. Chen H, et al. 2015. ASN Neuro 8:7. PubMed.
  4. Miyawaki T, et al. 2004. J Neurosci. 24(37): 8124-34. (IHC-F)
Product Citations
  1. Jadhav U et al. 2017. Cell stem cell. 21(1):65-77 . PubMed
  2. Wei Y, et al. 2021. Elife. 10: . PubMed
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  6. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
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  8. Chen J, et al. 2021. Sci Adv. 7:. PubMed
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  11. Zhang X, et al. 2020. Cell Reports. 28(3):792-803.e4.. PubMed
  12. Nawaz A, et al. 2022. Nat Commun. 13:7058. PubMed
  13. Paris AJ, et al. 2020. Nat Cell Biol. 1.747916667. PubMed
  14. Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
  15. Ghelman J, et al. 2021. Glia. 69(11):2699-2716. PubMed
  16. Wang B,et al. 2017. Cell Discov.. 10.1038/celldisc.2017.36. PubMed
  17. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  18. Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
  19. Bahar Halpern K, et al. 2020. Nat Commun. 11:1936. PubMed
  20. Reddy A, et al. 2020. Cell. 183:62. PubMed
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  22. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
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  24. Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
  25. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  26. Ko T, et al. 2022. Nat Commun. 13:3275. PubMed
  27. Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
  28. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  29. Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
  30. Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
  31. Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
  32. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  33. Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
  34. Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
  35. Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
  36. Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
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  41. Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
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  45. Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
  46. Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
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AB_2043969 (BioLegend Cat. No. 135907)
AB_2043970 (BioLegend Cat. No. 135908)

Antigen Details

Alpha chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that forms homo- or hetero-dimers on the surface after ligand binding.

Expressed on embryonic tissues and mesenchymal-derived cells of adult mouse.

Play a role in wound healing and act as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils.
Cell Type
Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Mukouyama YS, et al. 2006. Proc Natl Acad Sci USA. 103(5):1551
2. Miyawaki T, et al. 2004. J Neurosci. 24(37):8124
3. Takakura N, et al. 1997. J Histochem Cytochem. 45(6):883

Gene ID
18595 View all products for this Gene ID
View information about CD140a on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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