APC anti-human LOX-1 Antibody

Pricing & Availability
15C4 (See other available formats)
Regulatory Status
Other Names
Mouse IgG2a, κ
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Product Citations
GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • 15C4_APC_LOX-1_Antibody_FC_041714.jpg
    GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
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358605 25 tests 129€
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358606 100 tests 300€
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Lectin-like oxidized LDL receptor 1 (LOX-1) also known as CLEC8A is a 31 kD single pass type II transmembrane protein and member of the C-type lectin superfamily. LOX-1 is a scavenger receptor and is involved in endocytosis, phagocytosis and cytokine production. CLEC8A is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognizes numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
LOX-1 ectodomain: Fc fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescent staining of acetone-fixed frozen human skin sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Li D, et al. 2012. J. Exp. Med. 209:109. (IHC)
Product Citations
  1. Weed DT, et al. 2019. Front Immunol. 10:1206. PubMed
  2. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  3. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  4. Chmielowski R, et al. 2017. Acta Biomaterialia. 10.1016/j.actbio.2017.05.029. PubMed
AB_2563472 (BioLegend Cat. No. 358605)
AB_2563473 (BioLegend Cat. No. 358606)

Antigen Details

Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily.
Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; Upregulated by inflammatory and oxidative stimuli
Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, oxidized LDL
Cell Type
Endothelial cells, Platelets, Fibroblasts, Macrophages, Dendritic cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules
Antigen References

1. Yin Y, et al. 2013. Eur. J. Cell Biol. 92:150. 
2. Khaidakov M. and Mehta JL. 2012. PLoS One. 7:e46973. 
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439. 
4. Lin FY, et al. 2011. J. Immunol. 186:4405. 
5. Parlato S, et al. 2010. Blood 115:1554.

Gene ID
4973 View all products for this Gene ID
View information about LOX-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/29/2014

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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