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APC anti-human LOX-1 Antibody

Pricing & Availability
Clone
15C4 (See other available formats)
Regulatory Status
RUO
Other Names
OLR1, LOX1, LOXIN, SLOX1, CLEC8A, SCARE1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
15C4_APC_LOX-1_Antibody_FC_041714.jpg
GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • 15C4_APC_LOX-1_Antibody_FC_041714.jpg
    GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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358605 25 tests 129€
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358606 100 tests 300€
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Description

Lectin-like oxidized LDL receptor 1 (LOX-1) also known as CLEC8A is a 31 kD single pass type II transmembrane protein and member of the C-type lectin superfamily. LOX-1 is a scavenger receptor and is involved in endocytosis, phagocytosis and cytokine production. CLEC8A is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognizes numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
LOX-1 ectodomain: Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescent staining of acetone-fixed frozen human skin sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Li D, et al. 2012. J. Exp. Med. 209:109. (IHC)
Product Citations
  1. Weed DT, et al. 2019. Front Immunol. 10:1206. PubMed
  2. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  3. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  4. Chmielowski R, et al. 2017. Acta Biomaterialia. 10.1016/j.actbio.2017.05.029. PubMed
RRID
AB_2563472 (BioLegend Cat. No. 358605)
AB_2563473 (BioLegend Cat. No. 358606)

Antigen Details

Structure
Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily.
Distribution
Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; Upregulated by inflammatory and oxidative stimuli
Function
Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
Ligand/Receptor
Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, oxidized LDL
Cell Type
Endothelial cells, Platelets, Fibroblasts, Macrophages, Dendritic cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules
Antigen References

1. Yin Y, et al. 2013. Eur. J. Cell Biol. 92:150. 
2. Khaidakov M. and Mehta JL. 2012. PLoS One. 7:e46973. 
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439. 
4. Lin FY, et al. 2011. J. Immunol. 186:4405. 
5. Parlato S, et al. 2010. Blood 115:1554.

Gene ID
4973 View all products for this Gene ID
UniProt
View information about LOX-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/29/2014

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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