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APC anti-human CD156c (ADAM10) Antibody

Pricing & Availability
Clone
SHM14 (See other available formats)
Regulatory Status
RUO
Other Names
MADM, KUZ, alpha-secretase
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SHM14_APC_ADAM10_Antibody_FC_022014
Human peripheral blood lymphocytes were stained with ADAM10 (clone SHM14) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
  • SHM14_APC_ADAM10_Antibody_FC_022014
    Human peripheral blood lymphocytes were stained with ADAM10 (clone SHM14) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
352705 25 tests 124€
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352706 100 tests 294€
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Description

CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types.  It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human A375 cell lines
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Shemesh A, et al. 2022. J Exp Med. 219:. PubMed
RRID
AB_2563172 (BioLegend Cat. No. 352705)
AB_2563173 (BioLegend Cat. No. 352706)

Antigen Details

Structure
Consist of signal sequence, a N-terminal prodomain followed by a catalytic proteinase domain containing a zinc-binding motif, a disintegrin, cysteine-rich transmembrane, and a cytoplasmatic domain
Distribution

Ubiquitously expressed on most of the cell types

Function
Acts as an efficient α-secretase
Interaction
Proteolysis the amyloid precursor protein (APP)
Cell Type
B cells, Dendritic cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Signal Transduction
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Edwards DR, et al. 2008. Mol. Aspects Med. 29:258.
2. Anders A, et al. 2001. FASEB J. 15:1837.
3. Endres K, et al. 2010. FEBS J. 277:1585.
4. Mochizuki S, et al. 2007. Cancer Sci. 98:621.

Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD156c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 02/21/2014

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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