- GL3 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor γ/δ
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, which is involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. γ/δ TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8- although some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Armenian Hamster
- C57BL/6J intraepithelial lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Blue Laser (488 nm)
- Application Notes
The GL3 antibody has been shown to be useful in identifying γ/δ T cells by flow cytometry and immunohistochemistry and depleting γ/δ T cells in vivo. Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone-fixed frozen sections2,6, and in vivo depletion of γ/δ T cells3-5.
(PubMed link indicates BioLegend citation)
- Goodman T, et al. 1989. J. Exp. Med. 170:1569. (FC, IP)
- Cardona AE, et al. 2003. Infect. Immun. 71:2634. (IHC)
- Kapp JA, et al. 2004. Immunology 111:155. (Deplete)
- Skelsey ME, et al. 2001. J. Immunol. 166:4327. (Deplete)
- Ke Y, et al. 1997. J. Immunol. 158:3610. (Deplete)
- Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
- Kasten KR, et al. 2010. Infect. Immun. 78:4714. (FC) PubMed
- Stadanlick JE, et al. 2011. J. Immunol. 187:664. PubMed
- Van Belle AB, et al. 2012. J. Immunol. 188:462. PubMed
- Product Citations
AB_2562770 (BioLegend Cat. No. 118127)
AB_2562771 (BioLegend Cat. No. 118128)
- Ig superfamily, associates with CD3 complex.
T cell subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum, most γ/δ T cells are CD4-/CD8-, some are CD8+.
- Antigen recognition; γ/δ T cells are thought to play a role in tolerance.
- Some bacterial or tumor antigens bound to MHC class I.
- Cell Type
- Epithelial cells, T cells, Tregs
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
- Skarstein K, et al. 1995. Immunology. 81:497.
- Harrison LC, et al. 1996. J Exp Med. 184:2167.
- Wildner G, et al. 1996. Eur J Immunol. 26:2140.
- Brandes M, et al. 2005. Science. 309:264.
- Gene ID
- 110066 View all products for this Gene ID 110067 View all products for this Gene ID
- View information about TCR gamma/delta on UniProt.org
Related Pages & Pathways
Other FormatsView All TCR γ/δ Reagents Request Custom Conjugation
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Brilliant Violet 421™ anti-mouse TCR γ/δ
Purified anti-mouse TCR γ/δ
Biotin anti-mouse TCR γ/δ
FITC anti-mouse TCR γ/δ
PE anti-mouse TCR γ/δ
APC Anti-mouse TCR γ/δ
PerCP/Cyanine5.5 anti-mouse TCR γ/δ
PE/Cyanine7 anti-mouse TCR γ/δ
Alexa Fluor® 488 anti-mouse TCR γ/δ
Brilliant Violet 605™ anti-mouse TCR γ/δ
Brilliant Violet 510™ anti-mouse TCR γ/δ
Alexa Fluor® 647 anti-mouse TCR γ/δ
APC/Fire™ 750 anti-mouse TCR γ/δ
TotalSeq™-A0121 anti-mouse TCR γ/δ
Ultra-LEAF™ Purified anti-mouse TCR γ/δ
TotalSeq™-C0121 anti-mouse TCR γ/δ
APC/Cyanine7 anti-mouse TCR γ/δ
TotalSeq™-B0121 anti-mouse TCR γ/δ