- 9D3.1C8 (See other available formats)
- Other Names
- Interleukin-17F, ML-1,
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Interleukin 17F (IL-17F) is a 37 kD IL-17 family member. The IL-17 family consists of six members including IL-17 (also called IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17F shares the strongest similarity to IL-17A and forms a homodimer or heterodimer with IL-17A. It is produced by Th17 cells, mast cells, basophils, and epithelial cells. IL-17F is an important regulator of inflammatory responses. It is involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. Over expression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hyper-secretion. IL-17F is also involved in cancer immunity and autoimmune responses. IL-17F, like IL-17A, depends on IL-17R for its signaling in vitro and in vivo. P38 MAPK, ERK1/2, Act1 (NF-KB activator protein 1), and TRAF6 are involved in IL-17F signaling.Product Details
- Antibody Type
- Host Species
- Mouse IL-17F-OVA
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 488.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Blue Laser (488 nm)
(PubMed link indicates BioLegend citation)
- Obregon-Henao A, et al. 2013. PLoS One. 8:80669. PubMed
- Product Citations
AB_10660963 (BioLegend Cat. No. 517005)
AB_10661903 (BioLegend Cat. No. 517006)
- Forms a 37 kD homodimer or heterodimer with IL-17A of the IL-17 family member.
- Th17 cells, mast cells, basophils, and epithelial cells.
- An important regulator of inflammatory responses, involved in cancer immunity and autoimmune responses as well.
- IL-17R (CD217)
- Cell Type
- Th17, Mast cells, Basophils, Epithelial cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Dong C. 2008. Immunol. Rev. 226:80.
2. Kolls JK, et al. 2004. Immunity 21:467.
3. Aggarwal S, et al. 2002. J. Leukoc. Biol. 71:1.
4. Yang XO, et al. 2008. J. Exp. Med. 205:1063.
5. Ishigame H, et al. 2009. Immunity 30:108.
6. Hu Y, et al. 2010. J. Immunol. 184:4307.
- Gene ID
- 257630 View all products for this Gene ID
- View information about IL-17F on UniProt.org
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