Hematopoiesis from Multipotent Stem Cell
Hematopoietic stem cells (HSCs) are multipotent progenitors with the ability to give rise to all blood cell types. From the HSC, signaling through either SCF and TPO or IL-7 gives rise to the common myeloid progenitor (CMP) or the common lymphoid progenitor (CLP), respectively.
From the CMP, the presence of IL-4, SCF, and TPO result in differentiation into the megakaryocyte and erythroid progenitor while the presence of GM-CSF results in differentiation into a granulocyte and macrophage progenitor. These committed progenitors are able to mature into all myeloid cells including megakaryocytes, monocytes, macrophages, erythrocytes, and granulocytes. The specific cell subtype is determined by a number of internal and external cytokines and growth factors including Tpo, Epo, M-CSF, and G-CSF.
As its name indicates, the CLP has the ability to give rise to all lymphoid cells including T cells, B cells, and Natural Killer cells. Cytokines including IL-7, IL-2, and IL-4 help to determine cell fate as they progress into lineage-committed cells.
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