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| Plasticity is a hallmark of synapses where they can strengthen or weaken over time. When this occurs, protein nanomodules correspondingly increase in number as a synapse strengthens. The structural changes that occur as synapse changes are not completely understood, and Hruska et al. investigated how this occurs. They used a chemical long term potentiator (cLTP) to trigger a calcium influx through NMDAR. This led to an increase in dendritic spine size and a correlated increase in aligned nanomodules in both pre- and post-synapse areas, as identified by microscopy staining of VGLUT1 and PSD-95, respectively. BioLegend provides highly specific antibodies for both pre- and post-synaptic markers that are useful in microscopy and western blotting applications. In addition, our prices for these reagents have been decreased by up to 40% to help fit any researcher's budget. |
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| Adapted from Hruska, M. et al. 2018. Nat. Neuro. 21:671. Pubmed |
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 IHC staining of clone K28/74 on FFPE rat brain tissue. Purified anti-Pan-Shank Antibody  Staining of clone N23B/49 on FFPE rat brain tissue. |
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| We've updated our microscopy webpage to include more content, such as useful information on our directly-conjugated antibodies, cell health, and tips and tricks to help with your IHC and IF staining. Explore the webpage... |
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| In a land where reproducibility and publications are king, rogue reagents are making life difficult for researchers. Check out our new video to see how BioLegend is bringing order back to the Wild Western. Watch the video... |
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| Antibody validation is of the utmost importance to all areas of biological research. In applications like immunohistochemistry (IHC) and immunocytochemistry (ICC), it can be complicated to assess the effect of sample type and preparation on affinity and specificity of antibodies. BioLegend has been undertaking a program of extensive antibody validation of existing clones. For more information, view our infosheet... |
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