- 4H1B35 (See other available formats)
- Regulatory Status
- Other Names
- GP130, IL6ST, IL-6RB, IL-6R-beta, Oncostatin-M receptor subunit alpha, IL-6 receptor Beta
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
|149401||25 µg||118 CHF|
|149402||100 µg||265 CHF|
CD130, also known as gp130 and IL-6ST, is a type I transmembrane glycoprotein. CD130 can form receptor complexes for a family of cytokines, which include IL-6, IL-11, IL-27, LIF, and OSM, and can transduce signals for these cytokines. The 597aa extracellular domain has one Ig-like domain and five fibronectin type-III repeats. The 277a.a. intracellular domain does not have intrinsic kinase activity. Instead, it can be phosphorylated at tyrosine residues after it forms complexes with other receptor subunits, and in turn can lead to the association with JAK tyrosine kinases and the activation of STAT transcription factors, particularly STAT3.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant mouse CD130 (a.a. 23-619) expressed in 293E cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2565294 (BioLegend Cat. No. 149401)
AB_2565295 (BioLegend Cat. No. 149402)
- Single pass type 1 membrane glycoprotein.
T cells, activated B cells, plasma cells, and monocytes.
- Signal transduction.
- IL-6RA, IL-11RA, IL-27RA, OSMR, LIFR, CNTFR, JAK1, and SOCS3.
- Cell Type
- B cells, Dendritic cells, Monocytes, Plasma cells, T cells, Tregs
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
1. Hibi M, et al. 1990. Cell 63:1149.
2. Kishimoto T, et al. 1995. Blood 86:1243.
- Gene ID
- 16195 View all products for this Gene ID
- View information about CD130 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD130 Reagents Request Custom Conjugation
|Purified anti-mouse CD130 (gp130)||4H1B35||FC|
|PE anti-mouse CD130 (gp130)||4H1B35||FC|
|APC anti-mouse CD130 (gp130)||4H1B35||FC|
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