- A15032A (See other available formats)
- Regulatory Status
- Other Names
- Interleukin 1, alpha, IL-1A, IL1F1
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Avail.||Save|
|686502||100 µg||265 CHF|
IL-1 (Interleukin-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1RA, IL-36RA, IL-38), and an anti-inflammatory cytokine (IL-37). A tight regulation through receptor antagonists, decoy receptors, and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. The cytokine IL-1α is a key molecule in the IL-1 family that induces autonomous proliferation in vascular smooth muscle cells, T cell activation during antigen presentation, up-regulation of monocyte/macrophage-mediated tumor cytotoxicity, stimulation of osteoclast formation, and production of proteinases in human chondrocytes. Furthermore, IL-1α is also an early and important mediator of inflammation after injury.Product Details
- Antibody Type
- Host Species
- Human IL-1α, amino acids Ser113-Ala271 (Accession# NM_000575) was expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone A15032A weakly reacts with mouse IL-1a.
AB_2616884 (BioLegend Cat. No. 686502)
- 271 amino acids with the predicted molecular weight of approximately 31kD.
IL-1α is produced by monocytes, macrophages, keratinocytes, stimulated B lymphocytes, fibroblasts, endothelial cells, and epithelial cells.
- The cytokine IL-1α is a key molecule both in the innate and in the adaptive immune response. It induces autonomous proliferation in vascular smooth muscle cells, T cell activation during antigen presentation, up-regulation of monocyte/macrophage-mediated tumor cytotoxicity, stimulation of osteoclast formation, and production of proteinases in human chondrocytes.
- Stimulates thymocyte and B-cell proliferation.
- Type I and II IL-1 receptors (IL-1RA and IL-1RB).
- Cell Type
- B cells, Neutrophils
- Biology Area
- Angiogenesis, Cancer Biomarkers, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Antigen References
1. Ledford H. 2007. Nature 450:600.
2. Boraschi D, Tagliabue, A. 2006. Vitam. Horm. 74:229.
3. Shao J, Sheng H. 2007. J. Immunol. 178:4097.
4. Elaraj DM, et al. 2006. Clin. Cancer Res. 12:1088.
5. Schett G, et al. 2016. Nat. Rev. Rheumatol. 12:14.
6. Brough D, et al. 2015. IUBMB Life 67:323.
7. Dinarello CA, et al. 2014. Mol. Med. 20 Suppl. 1:S43-58.
8. Voronov E, et al. 2014. Front Physiol. 5:114.
9. Garlanda C, et al. 2013. Immunity 39:1003.
10. Rider P, et al. 2013. Semin. Immunol. 25:430.
- Gene ID
- 3552 View all products for this Gene ID
- View information about IL-1alpha on UniProt.org
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.