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- Clone
- 13F10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Actin-interacting protein 1
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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.JPG&Height=80&altFmImage_path=&Compression=90&Crop=5 "13F10_WB_051509")
NIH/3T3 (left) and Jurkat (right) cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with purified anti-mAIP1 (Clone 13F10) antibody. Proteins were visualized using an HRP goad anti-rat secondary antibody conjugate and a chemiluminescent detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 645601 | 25 µg | 124 CHF | ||||
AIP1(actin-interaction protein 1) is a 67 kD WD repeat protein known to regulate the depolymerization of actin filaments by cofilin and is conserved in organisms ranging from yeast to mammals. Recently, it was reported that caspase-11 and AIP1 cooperatively promote cofilin-mediated actin depolymerization.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Full length recombinant protein expressed in E Coli
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 - 1 µg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Li J, et al. 2007. Nature Cell Biology 9:276
- RRID
-
AB_2063814 (BioLegend Cat. No. 645601)
Antigen Details
- Structure
- A protein of 67-kd WD-repeat protein. It contains as many as 10 WD repeats which is characterized by homologous sequence of around 40 amino acids with Trip-Asp(WD) at the carboxyl ends.
- Function
- Enhance actin filament disassembly in the presence of actin-depolymerizing factor cofilin.
- Interaction
- AIP1 binds cofilin/actin depolymerization factor.
- Ligand/Receptor
- Caspase-11 interacts physically with AIP1 to promote cofilin-mediated actin depolymerization.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Antigen References
-
1. Voegtli WC, et al. 2003 J. Biol. Chem. 278:34373
2. Mohri K, et al. 2004. J. Biol. Chem. 279:31697 - Gene ID
- 22388 View all products for this Gene ID
- UniProt
- View information about AIP1 on UniProt.org
Related FAQs
Other Formats
View All AIP1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-AIP1 | 13F10 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-AIP1
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