PE anti-human Delta Opioid Receptor Antibody

Pricing & Availability
Clone
DOR7D2A4 (See other available formats)
Other Names
OPRD, DOR, hDOR
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
DOR7D2A4_PE_021009.jpg
Human Opiod Receptor-transfected cells stained with DOR7D2A4 PE
  • DOR7D2A4_PE_021009.jpg
    Human Opiod Receptor-transfected cells stained with DOR7D2A4 PE
See PE spectral data
Cat # Size Price Quantity Avail. Save
327206 100 tests 260 CHF
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Description

Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, µ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
HEK-293/human Delta Opioid Receptor
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2298899 (BioLegend Cat. No. 327206)

Antigen Details

Structure
Seven transmembrane G-protein coupled receptor
Distribution

Brain cortical area, including olfactory bulb, hippocampus, and amygdale, nucleus accumbens

Function
Inhibit cAMP production, increase phosphodiesterase activity, control anxiety, depression, and pain
Ligand/Receptor
enkephalins
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
GPCR
Antigen References

1. Simonin F, et al. 1994. Mol. Pharmacol. 46:1015.
2. Befort K, et al. 1994. Genomics 20:143.
3. Bzdega T, et al. 1993. Proc. Nat. Acad. Sci. 90:9305.
4. Jordan BA. And LA Devi. 1999. Nature 399:697.
5. Xue K, et al. 2002. Am. J. Med. Genet. 11:45.

Gene ID
4985 View all products for this Gene ID
UniProt
View information about Delta Opioid Receptor on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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