PE anti-human CD112 (Nectin-2) Antibody

Pricing & Availability
TX31 (See other available formats)
Regulatory Status
Other Names
Poliovirus Receptor Related 2 Protein (PRR2), Nectin-2, Hve B
Mouse IgG1, κ
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Product Citations
KG1a (human myeloid leukemia cell line) stained with TX31 PE
  • TX31_PE_110308.jpg
    KG1a (human myeloid leukemia cell line) stained with TX31 PE
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337409 25 tests 117 CHF
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337410 100 tests 317 CHF
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CD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34 positive stem cells, endothelial cells, epithelial cells, and neuronal cells. CD112 functions as a receptor for α-herpes viruses HSV-1 and pseudorabies virus (PRV). CD112 is an adhesion molecule involved in the formation of cell junction and regulation of NK- and T cell-mediated cytotoxicity through interaction with CD226 (DNAM-1) and other nectin family molecules.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications include: partially block CD226-Fc binding to CD112 transfectant cells and partially inhibit the cytotoxicity mediated by NK and T cells.

Application References

(PubMed link indicates BioLegend citation)
  1. Tahara-Hanaoka S, et al.. 2004. Int. Immunol. 16:533
  2. Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
  3. Gillory LA, 2013. PLoS One. 8:77753. PubMed
Product Citations
  1. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  2. Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed
  3. Poznanski SM, et al. 2018. Cancer Immunol Res. 1.065277778. PubMed
  4. Grandclaudon M, et al. 2019. Cell. 179:432. PubMed
  5. Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
  6. Gillory L, et al. 2013. PLoS One. 8:77753. PubMed
  7. Kaito Y, et al. 2022. Oncol Lett. 23:51. PubMed
  8. Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
  9. Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
  10. Siew Y, et al. 2015. Int Immunol. 27: 621 - 632. PubMed
AB_2174163 (BioLegend Cat. No. 337409)
AB_2269088 (BioLegend Cat. No. 337410)

Antigen Details

Type I transmembrane glycoprotein, Ig superfamily

Myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells.

Adhesion, receptor for some Herpes Viruses
CD226, CD155, Nectin-1, -3, and -4, Herpes Viruses
Cell Type
Dendritic cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, Mast cells, Megakaryocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Zola H et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Bachelet I, et al. 2006. J. Bio. Chem. 281:27190
3. Pende D, et al. 2006. Blood 107:2030
4. Bottino C, et al. 2003. J. Exp. Med. 198:557

Gene ID
5819 View all products for this Gene ID
View information about CD112 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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