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FITC anti-human CD105 Antibody

Pricing & Availability
Clone
43A3 (See other available formats)
Regulatory Status
RUO
Other Names
Endoglin
Isotype
Mouse IgG1, κ
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Product Citations
publications
43A3_FITC_050707
Human monocytic cell line THP-1 stained with 43A3 FITC
  • 43A3_FITC_050707
    Human monocytic cell line THP-1 stained with 43A3 FITC
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323203 25 tests 89 CHF
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323204 100 tests 171 CHF
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Description

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
L-cells transfected with human CD105
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Bühring HJ, et al. 1991. Leukemia 5:841.
  2. Vogel W, et al. 2002. Haematologica 88:126.
  3. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed
  4. HonMou O, et al. 2011. Brain. 134:1790. PubMed
  5. Herrera MB, et al. 2013. Hepatology. 57:311. PubMed
  6. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
Product Citations
  1. Xin Y, et al. 2021. Stem Cell Res Ther. 49:12. PubMed
  2. Okochi M, et al. 2008. Biochem Biophys Res Commun. 371:85. PubMed
  3. Ishizaka R, et al. 2012. Biomaterials. 33:2109. PubMed
  4. Vishnoi M, et al. 2018. Cancer Res. 78:5349. PubMed
  5. Han X, et al. 2020. Int J Oral Sci. 12:10. PubMed
  6. Jin J, et al. 2014. J Biosci Bioeng. 118:593. PubMed
  7. Kerr BA, et al. 2021. Experimental Cell Research. 399(2):112456. PubMed
  8. Uezumi A, al < 2014. Cell Death Dis. 5:1186. PubMed
  9. Zhang X, et al. 2010. Exp Biol Med. 235:1505. PubMed
  10. Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. PubMed
  11. Fiedorowicz M, et al. 2020. Sci Rep. 10:5379. PubMed
  12. Nodomi S, et al. 2016. Oncogene. 10.1038/onc.2016.72. PubMed
  13. Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed
  14. Keshtkar S, et al. 2021. Stem Cells Int. 8857457:2020. PubMed
  15. Wang LT, et al. 2020. Cell Rep. 32:108188. PubMed
  16. Khan M, et al. 2016. PLoS One. 11:e0165718. PubMed
  17. Motedayyen H, et al. 2017. BMC Res Notes. . 10.1186/s13104-017-2880-6. PubMed
  18. Herbst SA, et al. 2021. iScience. 24:103062. PubMed
  19. Aomatsu E, et al. 2014. Sci Rep. 4:3652. PubMed
  20. Xing D, et al. 2020. Cell Transplant. 29:963689720932142. PubMed
  21. He Z, et al. 2020. J Exp Clin Cancer Res. 39:140. PubMed
  22. Grisendi G, et al. 2010. Cytotherapy. 12:466. PubMed
  23. Liu Y, et al. 2018. Chin J Cancer. 37:2. PubMed
  24. Pauken CM, et al. 2021. Cancers (Basel). 13:. PubMed
  25. Vishnoi M, et al. 2019. Mol Oncol. 13(9): 1913. PubMed
  26. Hu J, et al. 2022. Stem Cell Res Ther. 13:349. PubMed
  27. Safi R, et al. 2021. Photodermatol Photoimmunol Photomed. 37:202. PubMed
  28. Sprouse ML, et al. 2019. Int J Mol Sci. 20:8. PubMed
  29. Liu Z, et al. 2018. Cancer Med. 10.1002/cam4.1584. PubMed
RRID
AB_755955 (BioLegend Cat. No. 323203)
AB_755956 (BioLegend Cat. No. 323204)

Antigen Details

Structure
Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
Distribution

Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells

Function
Modulates cellular response to TGF-ß, involved in vascular development and remodelling
Ligand/Receptor
TGF-ß1, TGF-ß3
Cell Type
Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes
Biology Area
Angiogenesis, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York.
2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.

Gene ID
2022 View all products for this Gene ID
UniProt
View information about CD105 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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