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Biotin anti-mouse CD104 Antibody

Pricing & Availability
Clone
346-11A (See other available formats)
Regulatory Status
RUO
Other Names
Integrin β4, β4 integrin, TSP-1180, ITGB4
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
346-11A_Biotin_032808
Mouse lung carcinoma cell line (Line 1) stained with biotinylated 346-11A, followed by Sav-PE.
  • 346-11A_Biotin_032808
    Mouse lung carcinoma cell line (Line 1) stained with biotinylated 346-11A, followed by Sav-PE.
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123603 50 µg 89 CHF
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Description

CD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Tumor-associated antigen TSP-180 from BALB/c lung carcinoma
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported (for the relevant formats) applications include: immunohistochemical staining1.

Application References

(PubMed link indicates BioLegend citation)
  1. Tennenbaum T, et al. 1993. Cancer Res. 53:4803. (IHC)
Product Citations
  1. Lv X, et al. 2022. Acta Pharm Sin B. 12:735. PubMed
  2. Best SA, et al. 2018. Cell Metab. 27:935. PubMed
RRID
AB_961034 (BioLegend Cat. No. 123603)

Antigen Details

Structure
Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)
Distribution

Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset

Function
Adhesion
Ligand/Receptor
Laminins, keratin filaments
Cell Type
Embryonic Stem Cells, Endothelial cells, Epithelial cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kennel SJ, et al. 1992. J. Cell Sciences 101:1992.

Gene ID
192897 View all products for this Gene ID
UniProt
View information about CD104 on UniProt.org

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 3    Revision Date: 06.20.2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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