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APC anti-rat NKG2A/C/E Antibody

Pricing & Availability
Clone
WEN28 (See other available formats)
Regulatory Status
RUO
Other Names
KLRC1, Killer Cell Lectin Like Receptor C1, KLRC2, Killer Cell Lectin Like Receptor C2, KLRC3, Killer Cell Lectin Like Receptor C3
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
WEN28_APC_NKG2A-C-E_Antibody_040518
Rat splenocytes were stained with anti-rat NKG2A/C/E APC (clone WEN28, left) or mouse IgG1, κ isotype control APC (right), followed by anti-rat CD161 FITC.
  • WEN28_APC_NKG2A-C-E_Antibody_040518
    Rat splenocytes were stained with anti-rat NKG2A/C/E APC (clone WEN28, left) or mouse IgG1, κ isotype control APC (right), followed by anti-rat CD161 FITC.
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250703 25 µg 113 CHF
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250704 100 µg 237 CHF
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Description

The NKG2 molecules are a family of lectin-like receptors that form heterodimers with CD94. NKG2/CD94 heterodimer are primarily expressed on NK cells, and a subset of CD8+ T cells. Studies of CD94/NKG2 heterodimers on NK cells have demonstrated that the NKG2 components transduce signals after ligand binding.  NKG2A transduces inhibitory signals, while NKG2C and NKG2E transduce activating signals.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant rat NKG2A-Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Sasther PC, et al, 2011, J Immunol, 187:6365
Product Citations
  1. Dodagatta-Marri E, et al. 2021. Cell Rep. 36:109309. PubMed
RRID
AB_2728227 (BioLegend Cat. No. 250703)
AB_2728228 (BioLegend Cat. No. 250704)

Antigen Details

Structure
Type II transmembrane protein
Distribution

NK cells, a subset of CD8+ T-lymphocytes.

Function
Signal transduction, Receptor for non-classical MHC Class I molecules
Interaction
DAP10, DAP12, CD94
Ligand/Receptor
Non-classical MHC Class I glycoproteins
Cell Type
NK cells, T cells
Biology Area
Immunology
Molecular Family
MHC Antigens
Antigen References
  1. Berg SF, et al. 1998. Eur J Immunol, 28:444.
  2. Vance RE, et al. 1999. J Exp Med. 190(12).
  3. Vance RE, et al. 1998. J Exp Med. 188(10).
  4. Flornes LM, et al. 2010, Immunogenetics, 62:521
  5. Dissen E, et al. 2008. Semin Immunol. 20:369
Gene ID
29683 View all products for this Gene ID 29684 View all products for this Gene ID 500338 View all products for this Gene ID
UniProt
View information about NKG2A on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 0    Revision Date: 04.05.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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