APC anti-human Siglec-10 Antibody

Pricing & Availability
5G6 (See other available formats)
Regulatory Status
Other Names
Sialic acid binding Ig-like lectin 10
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
Human peripheral blood lymphocytes were stained with CD19 FITC and Siglec-10 (clone 5G6) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 5G6_APC_1_033012
    Human peripheral blood lymphocytes were stained with CD19 FITC and Siglec-10 (clone 5G6) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 5G6_APC_2_033012
See APC spectral data
Cat # Size Price Quantity Check Availability Save
347606 100 tests 310,00 CHF
Check Availability

Need larger quantities of this item?
Request Bulk Quote

Siglec-10 is a lectin that specifically binds α-2,3- or α-2,6-linked sialic acid. It is a member of the Ig-superfamily and is expressed in monocytes, eosinophils, B cells, and a subset of NK cells. Siglec-10 is a single pass transmembrane protein. The extracellular domain contains one V-set Ig-like domain and three C2-set domains; the cytoplasmic domain contains one immunoreceptor tyrosine-based inhibitor motif (ITIM) which, after tyrosine-phosphorylation, recruits SH2-family phosphatases such as SHP-1 and PTPN6, resulting in the blocking of the signal transduction. CD24 and the vascular adhesion protein-1 (VAP-1) have been described as ligands of Siglec-10.

Product Details
Technical Data Sheet (pdf)

Product Details

Human, African Green
Antibody Type
Host Species
Recombinant Siglec-10 fused to human IgG Fc
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Munday J, et al. 2001. Biochem. J. 355:489
  2. Yokoi H, et al. 2006. Allergy. 61:769
  3. Kivi E, et al. 2009. Blood 114:5385
  4. Barkal AA, et al. 2019. Nature. 572(7769):392-396. (Agonist)
Product Citations
  1. Tecle E, et al. 2019. J Biol Chem. 294:11910. PubMed
AB_11203899 (BioLegend Cat. No. 347606)

Antigen Details

Lectin, belongs to the Ig-superfamily, has one V-set Ig-like domain and three C2-set domains, a single transmembrane domain and one immunoreceptor tyrosine-based inhibitor motif (ITIM) in the cytoplasmic domain

Monocytes, eosinophils, B cells, and a subset of NK cells

Cell adhesion, signal transduction
CD24, vascular adhesion protein-1 (VAP-1)
Inhibition of signal transduction by recruiting cytoplasmic phosphatases
Cell Type
B cells, Eosinophils, Monocytes, NK cells
Biology Area
Molecular Family
Siglec Molecules
Antigen References

1. Chen GY, et al. 2009. Science 323:1722
2. Aizawa H, et al. 2003. Genomics.82:521
3. Kitzig F, et al. 2002. Biochem Biophys Res Commun. 296:355

Gene ID
89790 View all products for this Gene ID
View information about Siglec-10 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Insert Note Here
Save Close Clear
Lab Timer
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account