Cancer development is strongly associated with an uncontrolled inflammatory state, and is often described as a wound that doesn't heal. Macrophages that infiltrate tumors are known as Tumor Associated Macrophages (TAM). In early stages, M1-like macrophages may fight tumors. But as the tumor microenvironment influences the mononuclear phagocyte population, the TAM get polarized towards the M2-like phenotype and promote cancer progression.

Tumor-Associated Macrophages (TAM)

Danger to control:


Micro-Environment factors involved:

Macrophage-related factors involved: