|Synapses contain hundreds of proteins that impact higher level functions like movement, cognition, and memory. Proteins like Neuroligin-1, SALM, and SynCAM are involved with adhesion, helping to create synapses and improve communication between neurons. Ionotropic receptors form a single pore that spans the membrane. Activation of the receptor by neurotransmitters causes the pore to open and allows the direct passage of ions such as Ca2+ through the membrane. Ligands such as glutamate are excitatory, whereas other ligands like GABA are inhibitory. BioLegend provides cost-effective reagents to study these factors, which are of particular importance in neurodegenerative diseases that weaken synaptic connections.|
|Purified anti-SALM2 (LRFN1) Antibody||Purified anti-VGlut2 Antibody|
|Staining of SALM2/LRFN1 on formalin-fixed paraffin-embedded rat brain tissue.||Western Blot showing VGlut2 (N29/29) specificity. Lane 1: Molecular weight marker; Lane 2: Mouse brain membrane lysate; Lane 3: BSA negative control.|
|Presynaptic Proteins||Postsynaptic Proteins||Adhesion Molecules|
SAPAP (pan reactive)
|GABAergic Receptors||Glutaminergic Receptors|
|BioLegend develops innovative reagents to support neuroscience research, with focus on the fields of neurodegeneration and neuroinflammation. We offer novel antibodies for detection of aggregate-specific species of α-Synuclein, a key protein involved in the pathogenesis of Parkinson’s disease.
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