- QA17A07 (See other available formats)
- Regulatory Status
- Other Names
- T8, Lyt2, Ly-2
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.Product Details
- Antibody Type
- Host Species
- Mouse thymus or spleen
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with Spark Violet™ 538 under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Spark Violet™ 538 has a maximum excitation of 396 nm and a maximum emission of 538 nm.
- Excitation Laser
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2890706 (BioLegend Cat. No. 155019)
- Ig superfamily, CD8α chain, 34 kD
Most thymocytes, T cell subset, some NK cells, lymphoid dendritic cells
- Co-receptor for TCR
- MHC class I molecule
- Cell Type
- Dendritic cells, NK cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
- Barclay AN, Brown MH. 1997. Biochem. Soc. Trans. 25:224-8.
- Zamoyska R. 1994. Immunity 1:243.
- Ellmeier W, et al. 1999. Annu. Rev. Immunol. 17:523.
- Gene ID
- 12525 View all products for this Gene ID
- View information about CD8a on UniProt.org
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