- SA214G2 (See other available formats)
- Regulatory Status
- Other Names
- CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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C-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.Product Details
- Antibody Type
- Host Species
- Mouse CD198 (CCR8)-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with Spark NIR™ 685 under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Spark NIR™ 685 has a maximum excitation of 665 nm and a maximum emission of 685 nm.
- Excitation Laser
Red Laser (633 nm)
AB_2892304 (BioLegend Cat. No. 150323)
AB_2892304 (BioLegend Cat. No. 150324)
- G-protein coupled receptor, 7 transmembrane regions, 41 kD.
Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.
- Chemotaxis, involved in thymocyte apoptosis
- CCL1 (SCY1,TCA-3)
- Cell Type
- Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
- Coghill JM, et al. 2013. Blood. 122:825.
- Islam SA, et al. 2011. Nat Immunol. 12:167.
- Hoshino A, et al. 2007. J Immunol. 178:5296.
- Qu C, et al. 2004. J Exp Med. 200:1231.
- Gene ID
- 12776 View all products for this Gene ID
- View information about CD198 on UniProt.org
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