- 1F07-2C01 (See other available formats)
- Regulatory Status
- Other Names
- Vascular endothelial growth factor (VEGF), VEGF-A
- Rat IgG, κ
- Ave. Rating
- Submit a Review
- Product Citations
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VEGF-A, also known as VEGF (vascular endothelial growth factor), is the founding member of the family including VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. Vascular endothelial growth factors (VEGFs) are a family of secreted glycoproteins that belongs to structurally related superfamily of dimeric growth factors with a cysteine knot motif. This superfamily includes platelet-derived growth factor (PDGF) and transforming growth factor (TGF) family. VEGF-A plays important roles in both vasculogenesis and angiogenesis, including tumor associated angiogenesis and vascular leakage. VEGF-A is produced by diverse cell types, including aortic vascular smooth muscle cells, keratinocytes, macrophages and many tumor cells. Oxygen tension is a key physiological regulator of VEGF-A gene expression.Product Details
- Antibody Type
- Host Species
- N-terminal 24 aa sequence of murine VEGF
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-F - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Immunohistochemistry: Clone 1F07-2C01 is recommended for IHC on saponin-treated frozen tissue sections at a concentration range of 5-10 µg/ml.
It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Reinders MEJ, et al. 2003. J. Clin. Invest. 112:1655.
- Kirsch AH, et al. 2012. Am J Physiol Renal Physiol. 303:569. PubMed.
- Product Citations
AB_2212504 (BioLegend Cat. No. 512901)
AB_2212503 (BioLegend Cat. No. 512902)
- cystine-knot growth factors
aortic vascular smooth muscle cells, keratinocytes, macrophages and many tumor cells
- Cell Targets
- endothelial cells
- VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1)
- Cell Type
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
1. Contreras A, et al. 2007. Am. J. Transpl. 7:155.
2. Lambrechts D and Carmeliet P. 2007. Biochim. Biophys. Acta. 1762:1109.
3. Tong JP and Yao YF. 2006. Clin. Biochem. 39:267.
4. Reinders MEJ, et al. 2003. J. Clin. Invest. 112:1655
5. Ferrara N,et al. 2003. Nat. Med. 9:669.
6. Shibuya M. 2001. Cell Struct. Funct. 26:25.
7. Senger DR, et al. 1983. Science 219:983.
- HIF-1, hypoxiaresponsiveness
- Gene ID
- 22339 View all products for this Gene ID
- Specificity (DOES NOT SHOW ON TDS):
- Specificity Alt (DOES NOT SHOW ON TDS):
- View information about VEGF-A on UniProt.org
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