- 1C2B07 (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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IL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.Product Details
- Antibody Type
- Host Species
- Full length mouse IL-31 recombinant protein expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2563557 (BioLegend Cat. No. 660602)
- 163 aa with a putative 23 aa signal peptide that is cleaved to generate a 140 aa mature protein.
- IL-31 belongs to the IL-6 family of cytokines and plays a role in skin inflammation.
- Binds to the IL-31 receptor complex that consists of two receptor subunits, IL31RA and OSMR.
- Biology Area
- Molecular Family
- Antigen References
1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
2. Arai I, et al. 2013. Exp. Dermatol. 22:669.
3. Dai X, et al. 2013. PLoS One. 8:e67666.
4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
6. Dillon SR, et al. 2004. Nat. Immunol. 5:752.
- Gene ID
- 76399 View all products for this Gene ID
- Specificity (DOES NOT SHOW ON TDS):
- Specificity Alt (DOES NOT SHOW ON TDS):
- View information about IL-31 on UniProt.org
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