Purified anti-mouse CD83 Antibody

Pricing & Availability
Clone
Michel-19 (See other available formats)
Regulatory Status
RUO
Other Names
HB15
Isotype
Rat IgG1, κ
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Product Citations
publications
Michel-19_Purified_083107
mCD83 transfected cells stained with purified Michel-19, followed by anti-rat IgG FITC
  • Michel-19_Purified_083107
    mCD83 transfected cells stained with purified Michel-19, followed by anti-rat IgG FITC
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121502 100 µg $175.00
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Description

CD83 is a 45 kD type I transmembrane protein. It belongs to immunoglobulin superfamily and is expressed on mature dendritic cells and activated lymphocytes. CD83 is involved in the regulation of T cell development and immune response. Soluble form CD83 has been reported to inhibit dendritic cell maturation and dendritic cell-mediated T cell proliferation. Murine CD83 ligand has been found on B cells.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse CD83 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for relevant formats of this clone) include: immunohistochemistry of acetone - fixed frozen sections4.

Application References

(PubMed link indicates BioLegend citation)
  1. Cramer SO, et al. 2000. Int. Immunol. 12:1347.
  2. Fujimoto Y, et al. 2002. Cell 108:755.
  3. Mott KR, et al. 2009. Virol J. 6:56. (FC) PubMed
  4. Roland Cl, et al. 2009. Mol Cancer Res. 8:1761. (IHC) PubMed
  5. Masuda Y, et al. 2010. Cancer Immunol Immunother. [Epub ahead of print] (FC) PubMed
  6. Tze LE, et al. 2011. J Exp Med. PubMed
  7. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
Product Citations
  1. Tze L, et al. 2011. J Exp Med. 208:149. PubMed
RRID
AB_572023 (BioLegend Cat. No. 121502)

Antigen Details

Structure
Type I transmembrane protein, Ig superfamily, 45kD
Distribution

Mature dendritic cells, activated lymphocytes

Function
Regulate T cell development and immune response, soluble form CD83 inhibit dendritic cell maturation
Ligand/Receptor
CD83 ligand
Cell Type
Dendritic cells, Lymphocytes
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Lechmann M, et al. 2005. Biochem. Biophys. Res. Commun. 329:132.
2. Kotxor N, et al. 2004. Immunobiology 209:129.
3. Leon F, et al. 2004. J. Immunol. 173:2995.
4. Cramer SO, et al. 2000. Int. Immunol. 12:1347.
5. Fujimoto Y, et al. 2002. Cell 108:755.

Gene ID
12522 View all products for this Gene ID
UniProt
View information about CD83 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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